Table 1.
Docking scores against SARS-CoV-2-Mpro (PDB ID: 6Y2E) and predicted drug-likeness, lethal doses and bioavailability scores of individual anti-HIV drugs.
| Anti-HIV protease inhibitor drug | Docking score (kcal/mol) | Drug likeness | Lethal dose (kg/mg) | Bioavailability score |
|---|---|---|---|---|
| Amprenavir | –8.43 | 1.14 | 300 | 0.55 |
| ASC09/TMC-310911 | –9.56 | 1.09 | 150 | 0.17 |
| Atazanavir | –7.37 | 0.11 | 200 | 0.17 |
| Darunavir | –10.25 | 0.60 | 245 | 0.55 |
| Indinavir | –7.80 | 1.86 | 5000 | 0.55 |
| Lopinavir | –9.00 | 1.10 | 5000 | 0.55 |
| Nelfinavir | –9.97 | 1.41 | 600 | 0.55 |
| Ritonavir | –8.75 | 0.11 | 1000 | 0.17 |
| Saquinavir | –8.97 | 0.69 | 500 | 0.17 |
| Tipranavir | –10.14 | 0.72 | 333 | 0.56 |