Table 5.
Computationally predicted toxicity profiles including toxicity class of anti-HIV drug based on its chemical structure, using the tool, ProTox.
| Anti-HIV protease inhibitor drug | Hepato-toxicity | Carcino-genicity | Immuno-toxicity | Muta-genicity | Cyto-toxicity | Toxicity class |
|---|---|---|---|---|---|---|
| Amprenavir |  |
 |
|
|
|
III |
| ASC09/ TMC-310911 |  |
|
 |
|
|
III |
| Atazanavir | |
|
|
|
|
III |
| Darunavir | |
|
|
|
|
III |
| Lopinavir | |
|
|
|
|
V |
| Indinavir | |
|
|
|
|
V |
| Nelfinavir | |
|
|
|
|
IV |
| Ritonavir | |
|
|
|
|
IV |
| Saquinavir | |
|
|
|
|
IV |
| Tipranavir | |
|
|
|
|
IV |
The green-color indicates safer and the light cyan-color indicate moderate safer chemical and on other hand, red color indicates the toxic/hazard class of chemical and light pink indicates moderate toxic in nature.