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. 2020 Aug 10;23(3):584–591. doi: 10.1093/ntr/ntaa135

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Changes in biomarkers of exposure over time in the CEVal-compliant population. Plots show absolute levels of 24-hour urinary excretion of (A) 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), (B) monohydroxybutenyl-mercapturic acid (MHBMA), (C) S-phenylmercapturic acid (S-PMA), and (D) exhaled breath carbon monoxide (eCO) at baseline (day 1, all groups) and at days 30, 60, and 90 (smokers at baseline [Groups A, B, and D]) or at day 90 (never-smokers [Group E]). Data are presented as means ± CI in subjects in the CEVal-compliant population who continued to smoke combustible cigarettes (Group A; n = 32), switched to using glo (Group B; n = 60), abstained from cigarette smoking (Group D; n = 107), or were never-smokers (Group E; n = 35). The legend in panel A is applicable to all other panels.

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