Table 1.

Stress regulation of CRH-BP in invertebrates and non-mammalian vertebrates

Species / Model	Stressor	Region	Stress duration	Effect on BP mRNA	Reference
INVERTEBRATES
Honeybee	UV light	Head	1-4 hrs	Increase	Liu et al (2011)
	Cold	Head	1-4 hrs	Increase	Liu et al (2011)
	Heat	Head	1-4 hrs	Increase	Liu et al (2011)
Copepod	Heat	Whole body	90 min heat stress	Increase	Lee et al (2008)
	Salinity	Whole body	12 hr salinity	Increase	Lee et al (2008)
NON-MAMMALIAN VERTEBRATES
Gilthead sea bream	Salinity	Brain	up to 24 hrs	Increase	Martos-Sitcha et al (2014)
Sea lamprey	Salinity	Brain	30 min (for 24 hrs)	No effect	Endsin et al (2017)
	Heat	Tail	6 hrs	No effect	Boorse et al (2006)
Sole	Air	Hypothalamus	30 sec	No effect	Lopez-Olmeda et al (2013)
Carp	Hypoxia	POA	24 hrs	Decrease	Bernier et al (2012)
Rainbow trout	Hypoxia	Whole larvae	90 min or 24 hrs	Decrease in CRHBP (28 & 42 dpf)	Fuzzen et al (2011)
	Hypoxia	Telencephalon / POA	8 or 24 hrs	Increase in Telen/POA @ 24 hrs	Alderman et al (2008)
	Hypoxia	Tail	6 hrs	Decrease	Boorse et al (2006)
Carp	Infection	Gills & skin	3 week s	Decrease	Mazon et al (2006)
Rainbow trout	Physical disturbance	Pituitary	Single or repeated (3x)	Increase (repeated)	Doyon et al (2005)
Carp	Restraint	Hypothalamus	30 min or 24 hrs	Increase (24 hr restraint)	Huising et al (2004); Pijanowski et al (2015)
	Restraint	Pituitary	24 hrs	No effect	Huising et al (2004); Pijanowski et al (2015)
	Restraint	Gills & skin	24 hrs	Decrease	Mazon et al (2006)
Rainbow trout	Confinement or isolation	Pituitary	4, 24 or 72 hrs	No effect	Doyon et al (2005)
Cichlid	Social dominance	Brain or pituitary	4 weeks	Lower in dominant (pit), no effect in brain	Chen et al (2008)
Rainbow trout	Social stress	Telencephalon / POA	5 days	No effect	Jeffrey et al (2012)
	Social stress	Telencephalon / hypothalamus	8 or 24 hrs	Increase in telen of subord @ 24 hr, Decrease in hypothal of domin	Alderman et al (2008)
	Social stress + restraint	POA	5 days (dominance), 1 hr (restraint)	Increase (restraint)	Jeffrey et al (2014)
Gilthead sea bream	Starvation	Brain	up to 3 weeks	Decrease	Martos-Sitcha et al (2014)
Sole	Food deprivation	Whole larvae	3-12 days	Decrease	Wunderink et a, (2012)
Rainbow trout	Stocking density + decrease water	Telencephalon	30 min (water level)	No effect	Moltesen et al (2016)
Sole	Stocking density + hypersalinity	Brain	33 days (stocking density) / 1-7 days (salinity)	No effect (stocking density). Increase (high salinity, 24 hrs)	Wunderink et al (2011)
Salmon	UCS	POA	23 days	No effect	Madaro et al (2015)
Zebrafish	UCS	Telencephalon	21 days	No effect	Manuel et al (2014)