Table 2.

Stress regulation of CRH-BP in rodents

Regulator	Species	Region / Cell type	Stressor / Treatment	Effect on CRH-BP expression	References
Stress	Rat	Pituitary	Acute restraint stress	Increased CRH-BP mRNA	McClennen et al., 1998
	Mouse	Pituitary	Acute restraint stress	Increased CRH-BP mRNA and protein	Stinnett et al., 2015
	Rat	Basolateral amygdala	Acute restraint stress	Increased CRH-BP mRNA	Herringa et al., 2004; Lombardo et al., 2001
	Rat	Amygdala	Chronic restraint stress	Decreased CRH-BP mRNA	Pisarska et al., 2000
	Rat	Amygdala	Predator stress	Increased CRH-BP mRNA	Roseboom et al., 2007
	Rat	Basolateral amygdala, pituitary, and medial POA	Food deprivation (Lean and obese Zucker rats)	Increased CRH-BP mRNA in basolateral amygdala and medial POA Decreased CRH-BP mRNA in the pituitary	Timofeeva et al., 1999
	Rat	Medial POA	Treadmill running	Increased CRH-BP mRNA and protein	Timofeeva et al., 2003
	Rat	Amygdala and PVN	Prenatal stress	Decreased CRH-BP mRNA in PVN and amygdala	Zohar and Weinstock, 2011
Glucocorticoids	Rat	Pituitary	Adrenalectomy	Increased CRH-BP mRNA	McClennen et al., 1998
	Rat	Basolateral Amygdala	Corticosterone injection (sc)	No effect on CRH-BP mRNA	Herringa et al., 2006
	Rat	Fetal amygdalar cells	Dexamethasone	Increased CRH-BP mRNA, protein, and promoter activity	Kasckow et al., 1999
	Rat	Immortalized amygdalar cells	Dexamethasone	Increased CRH-BP mRNA and protein	Mulchahey et al., 1999
	Rat	Adrenal PC12 cells	Dexamethasone	Increased CRH-BP protein	Chatzaki et al., 2002
	Rat	Primary astrocytes	Dexamethasone (+TPA or forskolin)	Decreased secreted CRH-BP	Maciejewski et al., 1996
	Rat	Primary astrocytes	Dexamethasone (+CRH, TPA, or forskolin)	Decreased CRH-BP mRNA and hnRNA	McClennen et al., 1999
CRH	Rat	Basolateral amygdala	CRH injection (icv)	Increased CRH-BP mRNA	Herringa et al., 2006
	Rat	Fetal amygdalar cells	CRH	Increased CRH-BP mRNA, protein, and promoter activity	Kasckow et al., 1999
	Rat	Pituitary AtT-20 cells	CRH	Increased CRH-BP promoter activity	Cortright et al., 1997
	Rat	Adrenal PC12 cells	CRH	Increased CRH-BP protein	Chatzaki et al., 2002
	Rat	Primary astrocytes	CRH	Increased CRH-BP mRNA	McClennen et al., 1999