Table 3.
CRHBP SNPs in stress-related disorders
| CRHBP SNPs | Location | Association | Population | Reference |
|---|---|---|---|---|
| rs10055255 | Intron 6 | Depressive symptoms after citalopram | Major depressive disorder (STAR*D) | Binder et al., 2010 |
| Stress-induced alcohol craving | Heavy drinkers | Ray, 2011 | ||
| Post-ICU PTSD and depressive symptoms | ICU patients | Davydow et al., 2014 | ||
| Stress-induced negative affect and negative consequences of drinking | Heavy drinkers | Tartter and Ray, 2012 | ||
| rs10473984 | 3′-Flanking | Cortisol reactivity | Three-year-old children | Sheikh et al., 2013 |
| Depressive symptoms after citalopram treatment | Major depressive disorder (STAR*D) | Binder et al., 2010 | ||
| rs10474485 | 3′-Flanking | Depressive symptoms after citalopram treatment | Major depressive disorder (STAR*D) | Binder et al., 2010 |
| Emotional state | Irritable Bowel Syndrome patients, Japan | Sasaki et al., 2016 | ||
| Childhood trauma and suicide attempt | African Americans | Roy et al., 2012 | ||
| Anxiety disorders | Plains Indians | Enoch et al., 2008 | ||
| History of depressive symptoms | Alcohol dependence, Ireland | Kertes et al., 2011 | ||
| rs1715747* | 3′-Flanking | History of depressive symptoms | Alcohol dependence, Ireland | Kertes et al., 2011 |
| Anxiety disorders, EEG alpha power | Plains Indians | Enoch et al., 2008 | ||
| Alcohol use disorders, EEG alpha power | U.S. Caucasians | Enoch et al., 2008 | ||
| rs1875999 | 3′-UTR | Major depressive disorder | Major depressive disorder, Sweden | Claes et al., 2003 |
| Anxiety disorders, EEG alpha power | Plains Indians | Enoch et al., 2008 | ||
| Alcohol use disorders | U.S. Caucasians | Enoch et al., 2008 | ||
| Suicide attempt | Schizophrenia | De Luca et al., 2010 | ||
| Major depressive disorder | Major depressive disorder, Swedish males | Van Den Eede et al., 2007 | ||
| rs7728378 | Intron 6 | Major depressive disorder | Major depressive disorder, Swedish males | Van Den Eede et al., 2007 |
| Major depressive disorder | Major depressive disorder, Sweden | Claes et al., 2003 | ||
| Anxiety disorders, EEG alpha power | Plains Indians | Enoch et al., 2008 | ||
| Alcohol use disorders, EEG alpha power | U.S. Caucasians | Enoch et al., 2008 | ||
| Childhood trauma and suicide attempt | African Americans | Roy et al., 2012 | ||
| rs6453267 | Intron 5 | Childhood trauma and suicide attempt | African Americans | Roy et al., 2012 |
| rs1500 | 3′-Flanking | Anxiety disorders, EEG alpha power | Plains Indians | Enoch et al., 2008 |
| rs3811939 | Intron 3 | Alcohol use disorders | Schizophrenia (Gottingen Research Association for Schizophrenia sample) | Ribbe et al., 2011 |
*
Previously called rs7704995