Figure 3.

Shown are the various GSDMB (gasdermin-B) transcript isoforms and their relationship to their mapped genomic position on chromosome 17. GSDMB is transcribed from the reverse strand; hence, the exons (labeled at the bottom of the figure) are numbered in order from right to left. The thicker boxes denote regions that are transcribed: yellow signifies the untranslated regions, and blue signifies the translated regions. The bottom arrow shows the location of the start codon and the direction of translation. Dashed lines are intronic regions not included in the final transcript isoform. The footnote for each transcript isoform denotes the resulting product encoded: *protein with 403 amino acids (GSDMB-1), ^†protein with 416 amino acids (GSDMB-3), ^‡protein with 394 amino acids (GSDMB-2), ^§no protein because of retained intron, ^||nonsense-mediated decay, and ^¶protein with 407 amino acids (GSDMB-4).