Table 2.

Meta-analysis of Associations with Early Asthma Age at the 17q12–21.1 Locus among Three Cohorts with African American Participants (n = 5,630)^*

Association Rank	Variant	Chromosome 17 Position†	Allele 1	Allele 2	Allele 1 Frequency‡	Odds Ratio	P Value§	R2 with rs11078928‖	P Value, Adjusted¶
1	rs11078928	39,908,216	C	T	0.147	0.734	1.47 × 10−7	1.000	NA
2	rs34120102	39,869,782	A	G	0.151	0.737	1.75 × 10−7	0.954	7.62 × 10−1
3	rs12949100	39,900,936	A	G	0.147	0.737	1.99 × 10−7	1.000	3.75 × 10−1
4	rs12232497	39,883,866	C	T	0.152	0.739	2.18 × 10−7	0.964	9.88 × 10−1
5	rs35736272	39,876,427	C	T	0.152	0.741	2.58 × 10−7	0.964	8.44 × 10−1
6	rs12939832	39,908,623	A	G	0.146	0.739	2.67 × 10−7	0.995	3.40 × 10−1
7	rs2305480	39,905,943	A	G	0.154	0.747	4.04 × 10−7	0.950	9.68 × 10−1
8	rs4795398	39,881,926	T	C	0.154	0.747	4.33 × 10−7	0.951	7.59 × 10−1
9	rs35569035	39,879,371	T	C	0.154	0.748	5.40 × 10−7	0.951	6.31 × 10−1
10	rs12936409	39,887,396	T	C	0.154	0.749	5.62 × 10−7	0.951	6.01 × 10−1
11	rs10852935	39,875,421	T	C	0.156	0.751	6.59 × 10−7	0.938	6.64 × 10−1
12	rs34189114	39,876,207	T	C	0.164	0.762	1.41 × 10−6	0.885	7.17 × 10−1
13	rs34074973	39,879,513	G	GAGA	0.164	0.763	1.60 × 10−6	0.885	6.64 × 10−1
14	rs11557466	39,868,373	T	C	0.164	0.763	1.64 × 10−6	0.882	6.66 × 10−1
15	rs4795400	39,910,767	T	C	0.169	0.770	1.64 × 10−6	0.856	9.00 × 10−1
16	rs11078925	39,868,955	C	T	0.164	0.763	1.65 × 10−6	0.885	6.56 × 10−1
17	rs5820308	39,913,111	TCAAAA	T	0.163	0.771	2.29 × 10−6	0.868	9.56 × 10−1
18	rs62067029	39,882,138	T	A	0.154	0.686	2.58 × 10−6	0.951	3.38 × 10−1
19	rs17608925	39,926,578	C	T	0.060	0.666	6.76 × 10−6	0.340	6.37 × 10−2
20	rs59716545	39,875,604	G	T	0.164	0.706	9.04 × 10−6	0.885	7.63 × 10−1
21	rs36000226	39,907,676	C	T	0.187	0.794	1.14 × 10−5	0.752	9.18 × 10−1
22	rs2305479	39,905,964	T	C	0.187	0.795	1.20 × 10−5	0.752	8.92 × 10−1
23	rs883770	39,907,128	T	C	0.187	0.795	1.26 × 10−5	0.752	8.97 × 10−1
24	rs8076131	39,924,659	G	A	0.187	0.797	1.33 × 10−5	0.737	9.44 × 10−1
25	rs56750287	39,906,691	C	A	0.179	0.794	1.42 × 10−5	0.794	6.25 × 10−1
26	rs62067034	39,907,485	T	C	0.187	0.797	1.44 × 10−5	0.752	8.44 × 10−1
27	rs11651596	39,899,863	C	T	0.255	0.818	1.49 × 10−5	0.525	3.77 × 10−1
28	rs907092	39,766,006	A	G	0.174	0.792	1.53 × 10−5	0.716	9.62 × 10−1
29	rs4795399	39,905,186	C	T	0.154	0.709	1.68 × 10−5	0.950	4.87 × 10−1

Definition of abbreviation: NA = not applicable.

^*Associations meta-analyzed across GCPD-A (Study of the Genetic Causes of Complex Pediatric Disorders–Asthma), SAGE II (Study of African Americans, Asthma, Genes and Environment), and SAPPHIRE (Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race–Ethnicity) using fixed-effect model. Case patients were individuals with reported asthma onset at an age of <5 years as compared with healthy control subjects. Associations below the threshold of P < 2.86 × 10⁻⁵ are listed.

^†Positions based on Genome Reference Consortium Human Build 38.

^‡Allele frequencies are based on results from the participants without asthma in SAPPHIRE cohort.

^§Genotypes were analyzed using an additive model for the number of copies of allele 1 (coded as 0, 1, or 2); models were adjusted for patient sex and the first three principal components for population structure.

^‖Linkage disequilibrium between given variant and rs11078928. Values of 1 imply perfect correlation between markers.

^¶P value for the genotype association with asthma status after adjusting for rs11078928 genotype.