Table 1.
Cytokines evaluated in the literature. Several cytokines have been investigated in MPN patients using different techniques from 1997 to present. Detailed information about each study will be presented in this review.
| Populations | Sample source | Cytokines | Technology | Authors | Years |
|---|---|---|---|---|---|
| ET = 8, PV = 6, CML = 25, MF = 1 | PB | sIL-2R | ELISA | Kawatani T | 1997 |
| ET = 20, PV = 10, CML = 15, MF = 10 | PB | TNFα, IL-1α, IL-1β, IL-2, sIL-2R, IL-6, IL-10 | ELISA | Bourantas KL | 1999 |
| ET = 31, PV = 22, CML = 17 | PB and BM | TPO, IL-6, sIL-6R, IL-11, SCF, IL-3, IL-8 | ELISA | Hui-chi HSU | 1999 |
| ET = 40, PV = 8, MF = 25, CML = 10, Control = 27 | PB | IL-1α, IL-1β, Il-2, sIL-2Ra, IL-6, TPO | ELISA | Panteli KE | 2005 |
| PV = 18 | PB and BM | IL-11, IL-8 | ELISA | Hermouet S | 2002 |
| PV = 10, SE = 6 | PB | EPO, VEGF | ELISA | Murphy P | 2002 |
| ET = 40, PV = 8, MF = 25, CML = 10, Control = 27 | PB | VEGF | ELISA | Panteli KE | 2007 |
| ET = 15, PV = 58, SE = 37 | PB and BM | IL-6, IL-8, IL-11, Leptin, HGF, MCP-1, TIMP-1, SCF | ELISA | Boissinot M | 2011 |
| HGF, IL-6, IL-11, C-MET | mRNA | ||||
| ET = 28, PV = 20 | PB | IL-10, IL-22, IL-23 | ELISA | Gangemi S | 2012 |
| ET = 5, PV = 5, MF = 10 | PB | 79 cytokines | Human cytokine array | HO CL | 2007 |
| PV = 65, MF = 127, Control = 35 | PB | IL-1β, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, EGF, etoxin, FGF-b, GM-CSF, HGF, IFN-α, IFN-γ, IP-10, MCP-1, MIG, MIP-1α, MIP-1β, RANTES, TNF-α,VEGF | Multiplex cytokine assay | Vaidya R | 2012 |
| PV = 65, MF = 127, Control = 35 | PB | Multiplex cytokine assay | Tefferi A | 2011 | |
| PV = 17, ET = 21 | PB | IL-1β, IL-4, IL-6,IL-8, IL-10, IL-12, GM-CSF, IFN-γ, MCP-1, PDGF-BB, TNF-α, VEGF, HGF | Multiplex cytokine assay | Pourcelot E | 2014 |
| ET = 5, PV = 15, MF = 41, Control = 18 | PB | sIL-2Ra | ELISA | Wang JC | 2014 |
| ET = 11, PV = 20, MF = 16, Control = 34 | PB | GM-CSF, IFN-α2, IFN-γ, IP-10, MCP-1,MIP-1α, MIP-1β, RANTES, TNF-α, IL-1β, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-17A | Multiplex cytokine assay | Cacemiro MDC | 2018 |
EPO, erythropoietin; FGF-b, fibroblast growth factor-basic; GM-CSF, granulocyte macrophage colony-stimulating factor; HGF, hepatocyte growth factor; IFN, interferon; IL, interleukin; IP-10, IFNγ–inducible protein 10; MCP-1, monocyte chemotactic protein-1; MIP, macrophage inflammatory protein; PDGF, platelet-derived growth factor; RANTES, regulated on activation normally T-cell expressed and secreted; SCF, stem cell factor; VEGF, vascular endothelial growth factor; TPO, thrombopoietin; TNF-α, tumor necrosis factor α.