TABLE 13.

Severe donor-related adverse events and rate by type of collection method in the United States, 2015 and 2017

			Number of severe donor-related adverse events*			Reaction rate
Year	Collection type	Donor age	Blood centers	Hospitals	Combined (95% CI)	Blood centers	Hospitals	Combined
2017	Whole blood collections	All Donors	11,078	951	12,029 (9251–14,807)	1:896	1:525	1:867 (0.12%)
		18 years and younger	3663	241	3904 (2681–5127)
		Older than 18 years	7415	709	8125 (6065–10,184)
	Apheresis collections	All Donors	2498	88	2585 (2072–3098)	1:937	1:1037	1:940 (0.11%)
		18 years and younger	244	4	248 (113–384)
		Older than 18 years	2253	84	2337 (1676–2998)
	All collections	All donors	13,576	1038	14,614 (11,664–17,564)	1:903	1:568	1:880 (0.11%)†
2015	Whole blood collections (manual, all donors)		11,996	2275	14,271 (9036–19,507)	1:854	1:237	1:756 (0.13)
	Apheresis collections (automated, all donors)		3335	156	3491 (1088–5894)	1:786	1:752	1:784 (0.13)
	All collections (all donors)		15,331	2431	17,762 (10,744–24,779)	1:839	1:270	1:762 (0.13)†

^*Severe donor-related adverse events were defined as events occurring in donors attributed to the donation process that include, for example, major allergic reaction, arterial puncture, loss of consciousness of a minute or more, loss of consciousness with injury, nerve irritation, etc.

^†The total number of collections was 12,855,000 in 2017 and 13,526,000 in 2015.