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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Nov 12;41(1):501–511. doi: 10.1161/ATVBAHA.120.315045

Table 3.

GWAS signal counts by trait and conservation (unadjusted analysis)

Conservation defined based on synteny:
No
signal		 Signal (col %) Total % Signal Test of non-
inferiority*
WHRadjBMI
(n=5635)		 Non-conserved 1315 80 (27.6%) 1395 5.7% 0.00796
Conserved 4030 210 4240 5.0%
BMI
(n=5635)		 Non-conserved 1308 87 (23.0%) 1395 6.2% 0.345
Conserved 3949 291 4240 6.9%
Height
(n=5319)		 Non-conserved 968 195 (20.0%) 1163 16.8% 0.212
Conserved 3375 781 4156 18.8%
HDL
(n=5395)		 Non-conserved 1208 12 (29.3%) 1220 1.0% <0.001
Conserved 4146 29 4175 0.7%
LDL
(n=5389)		 Non-conserved 1203 14 (36.8%) 1217 1.2% <0.001
Conserved 4148 24 4172 0.6%
TGs
(n=5389)		 Non-conserved 1204 13 (29.5%) 1217 1.1% <0.001
Conserved 4141 31 4172 0.7%
CAD
(n=5534)		 Non-conserved 1301 8 (33.3%) 1309 0.6% <0.001
Conserved 4209 16 4225 0.4%
T2D
(n=5616)		 Non-conserved 1354 22 (31.4%) 1376 1.6% <0.001
Conserved 4192 48 4240 1.1%
Conservation defined based on synteny and expression:
No
signal		 Signal (col %) Total % Signal Test of non-
inferiority*
WHRadjBMI
(n=5607)		 Non-conserved 3173 173 (59.9%) 3346 5.2% 0.0336
Conserved 2145 116 2261 5.1%
BMI
(n=5607)		 Non-conserved 3115 231 (61.3%) 3346 6.9% 0.0196
Conserved 2115 146 2261 6.5%
Height
(n=5292)		 Non-conserved 2481 579 (59.6%) 3060 18.9% 0.0160
Conserved 1840 392 2232 17.6%
HDL
(n=5368)		 Non-conserved 3100 28 (68.3%) 3128 0.9% <0.001
Conserved 2227 13 2240 0.6%
LDL
(n=5362)		 Non-conserved 3097 26 (68.4%) 3123 0.8% <0.001
Conserved 2227 12 2239 0.5%
TGs
(n=5362)		 Non-conserved 3094 29 (65.9%) 3123 0.9% <0.001
Conserved 2224 15 2239 0.7%
CAD
(n=5506)		 Non-conserved 3233 17 (70.8%) 3250 0.5% <0.001
Conserved 2249 7 2256 0.3%
T2D
(n=5588)		 Non-conserved 3280 47 (68.1%) 3327 1.4% <0.001
Conserved 2239 22 2261 1.0%
*

Test of non-inferiority is based on delta=0.01.