Table 3.
Myelopathy‐ and neuropathy‐predominant phenotypes: accompanying cancers, immunological findings, and paraclinical data.
| Pt no. Age/Gender | Neurological syndrome | Symptoms, signs | Cancer, potential immunologic contributors | NIF CBA Profile, CSF | MRI | CSF WCC/Pro/OCB/Co‐existing Ab | Neurophysiology & biopsy data |
|---|---|---|---|---|---|---|---|
| 35. M/64*, * | Myelopathy | Right‐sided weakness, bowel and bladder dysfunction. Wheel‐chair bound | Ehrlichosis preceding | H | Spinal cord: longitudinally extensive C2‐5 T2 changes; central enhancement. | 6//N/N/N | Cord biopsy revealed histiocyte‐rich lesion with myelin loss, scattered T lymphocytes |
| 36. M/59 | Myelopathy | Progressive weakness | ‐ | A | Brain/spine: diffuse T2 changes brain & spinal cord; enhancement | NA/NA/P | ‐ |
| 37. F/60 | Myeloneuropathy | Progressive painful paresthesias with upper limb and trigeminal distribution, leg spasticity | SCLC | AHL | ‐ | N | ‐ |
| 38. M/59*, * | Myeloneuropathy | Progressive painful neuropathy with trigeminal, trunk, & 4 limb distribution. Hearing loss. | ‐ | H | Brain: N; Spine:T2 hyperintensity T3 level; thickened lumbosacral nerve roots; T2 hyperintense femoral nerves R > Le | N/67/N/0 | Right sensorineural hearing loss, slow right blink response, slow somatosensory‐evoked potentials localizing to thoracic spinal cord, & axonal sensorimotor polyneuropathy |
| 39. F/43 | Lumbosacral polyradiculoneuropathy | Severe diffuse limb pain & weakness | ‐ | HL | Spine: N | 35/53/5 | ‐ |
| 40. M/65*, * | Lumbosacral polyradiculoneuropathy | Progressive limb weakness | Non‐Hodgkin lymphoma | H | Spine: enhancing anterior thecal sac & lumbosacral nerve roots | N/83/0/0 (cytology normal) | EMG lumbosacral radiculopathies |
| 41. M/45 | Multifocal motor neuropathy | Deep aching & progressive upper extremity weakness, neuropathy | ‐ | A |
Brain & spine: N |
N/50/N/0 | EMG: 50% partial conduction block right ulnar nerve; F‐wave prolonged |
A, alpha‐internexin; Ab, antibody; EMG, electromyography; F, female; H, heavy chain; HIV, human immunodeficiency virus; L, light chain; Le, left; M, male; N, normal; NA, not available; OCBs, oligoclonal bands (CSF‐exclusive); Pro, protein; P, positive; Pt no., patient number; R, right; RA, rheumatoid arthritis; SCLC, small cell lung cancer; WCC, white cell count.
*
Evaluated at Mayo Clinic.