Table 2.

Multivariable Model in Male and Female using multivariable Cox survival analysis (Backward Stepwise, Wald) after adjustment for possible influencing factors. ¹

Variables and subgroups	β	SE	Wald	P‐value	HR (95%CI)
Male
Diagnostic delay
>12 m					1.0 [Reference]
≤12 m	0.819	0.207	15.642	<0.001	2.269 (1.512, 3.405)
BMI at baseline
>18.70					1.0 [Reference]
≤18.70	1.103	0.222	24.767	<0.001	3.013 (1.951, 4.652)
ΔALSFRS‐R
≤0.63					1.0 [Reference]
>0.63	1.308	0.209	39.198	<0.001	3.699 (2.456, 5.571)
Creatinine at baseline
>61 μmol/L					1.0 [Reference]
≤61 μmol/L	0.488	0.17	8.253	0.004	1.629 (1.168, 2.273)
Female
Age of onset
≤ 55y					1.0 [Reference]
>55 y	0.922	0.252	13.387	<0.001	2.515 (1.534, 4.121)
Diagnostic delay
>12 m					1.0 [Reference]
≤12 m	0.976	0.26	14.101	<0.001	2.653 (1.594, 4.414)
BMI at baseline
>18.70					1.0 [Reference]
≤18.70	0.823	0.327	6.347	0.012	2.277 (1.200, 4.321)
ΔALSFRS‐R
≤0.63					1.0 [Reference]
>0.63	1.093	0.279	15.314	<0.001	2.984 (1.726, 5.158)
Creatinine at baseline
>52 μmol/L					1.0 [Reference]
≤52 μmol/L	0.517	0.243	4.526	0.033	1.677 (1.042, 2.699)

¹Possible influencing factors included age of onset, site of onset, diagnostic delay, BMI, ALSFRS‐R score, progression rate (ΔALSFRS‐R), use of riluzole, use of NIPPV, and acceptance of PEG.