Table 1.
Diagnostic performance of αSyn seeding aggregation assays on the BioFIND cohort using maximum fluorescence values.
|
RT‐QuICR (Caughey) |
PMCA (Soto) 1 |
RT‐QuIC‐FG (Green) 1 |
Concordant 2 | |
|---|---|---|---|---|
| Sensitivity | 97.2% (92.1‐99.4) | 95.2% (90.6‐98.0) | 96.2% (91.4‐98.7) | 98.0% (93.1‐99.8) |
| Specificity | 87.1% (78.0‐93.4) | 89.9% (83.8‐93.5) | 82.3% (76.0‐85.6) | 92.3% (83.0‐97.5) |
| PPV | 90.5% (83.7‐95.2) | 92.6% (88.1‐95.2) | 87.8% (83.5‐90.1) | 95.2% (89.2‐98.4) |
| NPV | 96.1% (89.0‐99.2) | 93.4% (87.1‐97.2) | 94.2% (87.0‐98.0) | 96.8% (88.8‐96.6) |
| AUC (ROC) | 92.14% | 92.56% | 89.23% | 95.17% |
Abbreviations: AUC (ROC), area under the receiver operator characteristics analysis curve using maximum fluorescence data; NPV, negative predictive value; PPV, positive predictive value.
Ranges in parentheses are 95% confidence intervals.
1
PMCA and RT‐QuIC‐FG results were obtained from the BioFIND data repository, which were deposited from a previous study (ref 14).
2
Calculated from concordant results across all three assays which include 102 PD and 65 HC subjects.