Table 2.
ROC analysis of individual RT‐QuICR assay parameters for PD diagnosis.
| Sensitivity | Specificity | PPV | NPV | AUC (ROC) | Threshold | |
|---|---|---|---|---|---|---|
| Max Fluor | 97.2% (92.1‐99.4) | 94.1% (86.8‐98.1) | 99.5% (89.7‐98.5) | 96.4% (89.8‐99.2) | 94.28% | >78462 au |
| AUC‐fluor | 96.3% (90.8‐99.0) | 94.1% (86.8‐98.1) | 95.4% (89.6‐98.5) | 95.2% (88.3‐98.7) | 94.87% | >1441404 au⋅h |
| T50 | 93.5% (87.1‐97.4) | 78.8% (68.6‐86.9) | 84.9% (77.2‐90.8) | 90.5% (81.5‐96.1) | 88.99% | <34.30 h |
| Lag | 98.1% (93.5‐99.8) | 83.5% (73.9‐90.7) | 88.3% (81.2‐93.5) | 97.3% (90.5‐99.7) | 91.55% | <27.85 h |
Ranges in parentheses are 95% confidence intervals.
Abbreviations: au, arbitrary units; AUC, area under curve; AUC‐fluor, AUC of fluorescence versus time plot; Lag, reaction time to threshold; Max Fluor, maximum fluorescence; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operator characteristics; T50, reaction time to reach half‐maximal fluorescence.