Table 1. Highly notable events in the applied rabies field related to detection, prevention, and control over the past decade.
Item | Reference |
---|---|
Discovery of new lyssavirus species | 4 |
Suggestion of rabies virus adaptation beyond carnivores and bats to other mammals, such as non-human primates | 5 |
Greater appreciation of wildlife reservoirs in previously considered “rabies-free” areas | 6 |
Recognition of additional antigen detection, serological, and molecular tests for very sensitive and specific lyssavirus diagnosis |
7 |
Recognizable shifts from animal culling to mass dog vaccination as a proven management strategy | 8 |
Planning for the global elimination of human rabies mediated via dogs by 2030 | 9 |
Greater focus upon local infiltration of wounds with scarce rabies immunoglobulins | 10 |
Availability of human monoclonal antibodies as an alternative to polyclonal rabies immunoglobulin | 11 |
Recommendations on dose-sparing and shorter 1 week human prophylaxis regimens | 12 |
Expansion of the distribution of vampire bats and rabies virus spread | 13,197 |
Support for pre-exposure vaccination for those in remote settings, such as children in communities with a high exposure rate to canine rabies virus and those at risk of vampire bat depredation |
14 |
In vitro alternatives to animal testing in the determination of vaccine potency | 15 |
Demonstration of compounds with repeatable in vitro anti-rabies virus activity | 16 |
Renewal of interest for the oral vaccination of free-ranging dogs against rabies | 17 |
Elimination of canine rabies in Mexico | 18 |
Expectations of Gavi support for human rabies vaccination | 19 |