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(A) A-to-G substitution by directing adenosine-to-inosine deaminase activity to endogenous RNA transcripts using dCas13-ADARDD. (B) C-to-U substitution by directing cytidine-to-uridine deaminase activity to endogenous RNA transcripts using dCas13-ADAR2dd. (C) Exon inclusion to the mRNA by using a fusion of dCasRx and splicing regulatory domains. ADAR, adenosine deaminase; RBFOX1, RNA-binding protein fox-1 homolog; RBM38, RNA-binding motif protein 38.
