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. 2021 Feb 12;15:557–576. doi: 10.2147/DDDT.S292417

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© 2021 Yin et al.

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Dissolution profiles of GKA-SNEDDS and GKA-suspension in (A) Simulated gastric fluid (pH 1.2). (B) Simulated intestinal fluid (pH 6.8). (C) The effective permeability coefficient (P_eff) of GKA-SNEDDS in rats’ duodenum and jejunum by single-pass intestinal perfusion model. Each value represents the mean ± SD (n = 3). ^#p < 0.05 and ^##p < 0.01 as compared to GKA- suspension group in duodenum, **p < 0.01 as compared to GKA-suspension group in jejunum. (D) Plasma concentration–time profiles of rats after oral administration of GKA-SNEDDS and GKA-suspension.