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. 2021 Feb 16;16(2):e0247020. doi: 10.1371/journal.pone.0247020

Fig 4. CYP4B1 expression was modulated by its gene alterations and DNA methylation in LUAD.

Fig 4

(A) Genetic alterations of CYP4B1 in LUAD. (B) Heatmap of CYP4B1 expression, DNA copy number alterations (gistic2 linear and gistic2 thresholded), and DNA methylation (Methylation 450k). (C) CYP4B1 expression correlates with its linear copy number values by linear regression analysis. (D) DNA methylation level of cg23440155 and cg23414387 sites is significantly upregulated in LUAD tissues when compared with adjacent normal tissues. (E) CYP4B1 expression correlates with cg23440155 and cg23414387 methylation levels by a linear regression analysis. LUAD, lung adenocarcinoma.