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. 2021 Feb 16;16(2):e0245986. doi: 10.1371/journal.pone.0245986

Fig 1. Sulforaphane ameliorates collagen-induced arthritis (CIA) in mice.

Fig 1

(A) Arthritis score. Three weeks after CIA induction, CIA mice were intraperitoneally injected with sulforaphane three times per week (n = 5 per group); *P < 0.001. (B) Histological examination of the joints of CIA mice treated with sulforaphane. Mice were sacrificed on day 46 after CIA induction and tissue sections from the joints were stained with hematoxylin and eosin, and Safranin O. The histological scores of inflammations, cartilage damage, and bone damage are shown. ***P < 0.001, **P < 0.01.