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. 2021 Feb 16;16(2):e0246190. doi: 10.1371/journal.pone.0246190

Table 1. Baseline characteristics of studies included in this meta-analysis.

study Place Median age Exposure history (No.) Patients (No.) Symptoms (No.) Comorbidities (No.) Mortality rate (%.) Total Score Total Quality
All Male Female Fever Cough Fatigue or Myalgia Diarrhea Dyspnea All Hypertension Diabetes Cardiovascular disease Chronic kidney disease
[18] China 56 73 191 119 72 180 151 44 9 56 91 58 36 2 28.27 10 Very Good
[19] China 3 85 62 23 78 19 50 16 50 58 32 19 3 8 Good
[20] China 57.00 140 71 69 110 90 90 18 44 90 42 17 2 9 Very Good
[21] China 59.00 174 76 98 136 56 47 21 42 43 37 32 13 9 Very Good
[22] China 1590 904 674 1351 1052 584 57 331 399 269 130 59 269 3.10 8 Good
[23] China 51.00 99 201 128 73 188 163 65 80 66 39 22 8 2 21.90 9 Very Good
[24] China 69.00 339 166 173 311 179 135 43 138 138 54 53 13 19.17 9 Very Good
[25] China 73.00 25 10 15 23 25 16 10 8 5 100.00 5 satisfactory
[26] U.S 7162 2692 784 647 213 6 satisfactory
[27] U.S 180 153 155 62 48 144 159 79 47 45 20 9 Very Good
[28] China 50.00 311 1012 524 488 761 531 170 152 231 114 46 27 15 9 Very Good
[1] China 49.00 27 41 30 11 40 31 18 1 22 13 6 8 6 14.63 8 Good
[29] China 99 67 32 82 81 1 2 31 50 11.00 7 Good
[12] China 56.00 12 138 75 63 136 82 96 14 43 64 43 14 20 4 4.30 9 Very Good
[30] China 17 9 8 12 13 4 2 3 1 7 Good
[11] China 47.00 1099 637 459 473 745 419 42 205 261 165 81 8 1.40 8 Good
[31] China 41.00 23 62 35 27 48 50 32 3 20 5 1 1 0.00 6 satisfactory
[32] China 0 80 39 41 63 30 18 1 30 38 1 0.00 7 Good
[33] China 57.00 0 137 61 76 112 66 44 11 26 27 13 14 10 11.68 8 Good
[34] China 40.00 61 31 30 60 39 35 6 3 12 5 1 0.00 9 Very Good
[35] China 52 35 17 51 40 6 33 21 9 5 61.54 6 satisfactory
[36] China 187 91 96 61 28 6 23.00 9 Very Good
[37] Italy 355 72 100.00 7 Good
[38] China 12 8 4 10 11 4 2 3 2 4 2 6 satisfactory
[39] China 9 5 4 8 5 4 1 0 1 0 0 3 Unsatisfactory
[40] China 31974 44672 22981 21691 2683 1102 873 2.30 8 Good
[10] China 38.00 0 78 39 39 34 8 5 7 Good
[41] China 63.00 701 367 334 213 297 233 100 14 16.10 9 Very Good
[42] China 57.00 193 95 98 171 134 75 35 70 105 66.32 10 Very Good
[43] China 62.00 274 171 103 249 185 137 77 120 133 93 47 23 4 41.24 9 Very Good
[44] China 72.50 82 54 28 64 53 38 10 52 62 46 15 17 8 Good
[45] China 5 4 1 5 5 3 5 2 1 8 Good
[46] China 64.00 416 205 211 334 144 55 16 117 127 60 10 Very Good
[47] China 54.00 116 67 49 43 18 5 9 Very Good
[48] US 21 11 11 17 18 7 10 52.40 7 Good
[49] China 54.00 203 108 95 181 122 16 10 3 88 43 16 16 8 12.80 9 Very Good
[50] China 50.00 91 37 54 65 55 40 21 3 15 8 0.00 6 satisfactory
[51] China 58.00 452 235 217 423 152 212 122 232 201 135 75 27 10 36.70 9 Very Good
[52] China 69 32 37 30 38 29 10 20 9 7 8 7.50 8 Good
[53] China 55.00 8 221 108 113 200 136 156 25 64 78 54 22 22 5.40 9 Very Good
[54] China 50.00 90 39 51 70 57 19 5 45 17 5 3 8 Good
[55] China 109 74 35 99 77 58 29 75 65 34 9 Very Good
[56] China 54.00 47 102 53 49 83 50 56 11 35 47 28 11 5 4 16.70 9 Very Good
[57] Italy 63.00 1591 1304 287 1043 509 180 223 36 9 Very Good
[58] US 63.00 5700 3437 2263 5700 3026 1808 268 21.00 9 Very Good
[59] China 68.00 54 24 13 48.10 6 satisfactory
[60] China 200 99 101 161 101 137 16 17.00 10 Very Good
[61] China 64.91 47 26 21 12 18 5 6 satisfactory
[62] China 110 60 50 57 19 16 9 9 Very Good
[63] China 61.00 323 166 157 271 164 14 105 47 7 9 Very Good
[64] China 49 31 18 39 17 9 4 6 16 6 satisfactory
[65] China 47.00 298 149 149 192 54 6 6 38 19 11 8 Good
[66] China 265 220 131 67 17 5 52 21 14 9 Very Good
[67] China 45.00 242 119 123 162 132 72 15 21 36 15 9 0.80 10 Very Good
[68] China 48.00 84 48 36 54 43 16 6 3 12 10 5 8 Good
[69] China 55.00 109 59 50 90 67 62 12 37 12 7 10 28.40 9 Very Good
[70] China 60.00 548 279 269 476 415 258 179 310 166 83 10 16.50 9 Very Good
[71] China 52.00 113 66 47 91 26 9 1.80 9 Very Good
[72] China 60.00 27 12 15 21 16 3 11 13 5 6 3 37.00 8 Good
[73] China 136 58 78 115 85 24 17 75 53 24 6 2 0.00 9 Very Good
[73] China 652 349 303 521 421 115 20 143 73 33 5 5 0.00 9 Very Good
[74] Bolivia 39.00 12 6 6 9 9 5 2 2 1 0.00 6 Satisfactory
[75] China 45.00 104 161 80 81 122 101 64 17 23 33 22 7 0.00 9 Very Good
[76] China 47.00 113 135 72 63 120 102 44 18 18 43 13 12 7 0.70 9 Very Good
[77] China 37 14 23 15 12 0 10 8 4 0.00 6 Satisfactory
[78] China 214 87 127 132 107 41 83 51 30 15 6 0.00 9 Very Good
[79] China 65.00 112 57 55 98 79 63 36 19 0.00 9 Very Good
[80] China 136 90 46 52 71 66 27 102 41 27 3 0.00 8 Good
[81] China 70.00 25 19 6 16 12 6 8 100.00 8 Good
[81] China 51.00 149 60 89 36 25 11 8 0.00 8 Good
[82] Singapore 47.00 18 9 9 13 15 3 2 5 4 1 5 unsatisfactory
[83] Korea 75.50 54 33 21 49 16 32 5 100.00 7 Good
[84] China 92 49 43 65 51 13 16 2 100.00 7 Good
[85] China 168 86 82 156 121 65 44 59 57 41 20 9 2 10.10 10 Very Good
[86] China 13 10 3 13 10 8 2 12 2 1 38.50 7 Good
[86] China 12 2 10 11 7 8 3 8 0 0 0.00 7 Good
[87] UK 82.00 101 64 37 9 4 9 3 67 54 36 18 21 74.20 8 Good
[88] China 2 3 2 1 1 2 1 2 0 1 0 0.00 6 satisfactory
[89] China 134 149 81 68 114 87 11 2 52 28 0.00 7 Good
[90] China 31 81 42 39 59 48 7 3 34 21 12 10 8 3 4.00 8 Good
[91] Korea 77.00 66 37 29 61 30 23 10 5 9 Very Good
[92] China 52.00 108 43 65 80 84 28 8 15 25 16 5 4 11.10 9 Very Good
[93] China 53.00 425 476 271 205 390 269 109 205 113 49 38 4 8.00 9 Very Good
[94] China 54.00 37 155 86 79 126 97 60 7 50 37 15 15 6 0.00 9 Very Good
[95] China 186 487 259 228 99 29 11 7 0.00 9 Very Good
[96] USA 72 167 55 112 74 38 68 43 21 8 Good
[97] Italy 65 410 229 111 203 69 47 10 Very Good
[98] USA 45 100 56 44 71 87 21 10 38 19 10 6 8 Good
[99] Italy 99 80 19 39 63 30 15 9 Very Good
[100] USA 69 105 53 52 49 76 51 24 56 62 35 40 27 33 9 Very Good
[101] Greece 21 17 4 7 2 0 0 9 Very Good
[101] Greece 24 18 6 11 4 3 1 9 Very Good
[101] Greece 45 37 8 27 11 16 3 9 Very Good
[102] Italy 68 236 177 59 230 144 83 37 127 15 10 Very Good
[103] USA 52.7 13442 7841 5957 3043 2710 2086 809 9 Very Good
[104] China 83 44 39 72 65 15 7 9 15 5 7 1 8 Good
[105] China 296 140 156 213 197 42 30 6.4 9 Very Good
[106] China 1590 904 674 1351 1052 584 57 331 399 269 130 59 8 Good
[107] Italy 68.00 6272 3968 2303 3631 859 1891 181 9 Very Good
[108] USA 18472 7388 11083 7388 3509 2216 10 Very Good
[109] UK 1200 686 513 645 417 160 206 10 Very Good
[110] USA 73.00 206 101 105 152 206 7131 10 Very Good
[5] Spain 69.10 1139 695 444 617 310 312 89 9 Very Good
[111] Belgium 86.00 154 51 103 39 28 181 6 Satisfactory
[112] USA 52.70 442 256 186 159 84 47 9 Very Good
[113] UK 68.00 605 272 333 200 30 90 206 10 Very Good
[114] UK 69.30 1474 787 686 728 228 138 7131 8 Good

*Abbreviations: No = Number.