Table 3.
Summary of Digital Medicine System Endpoints Based on IEM Detection (Intent-to-Treat Population)
| Schizophrenia (n = 18) | Schizoaffective Disorder (n = 9) | First-Episode Psychosis (n = 16) | Overall (n = 43) | |
|---|---|---|---|---|
| Adherence metric based on digital health dataa | ||||
| Mean (SD) | 88.9 (8.1) | 72.3 (25.7) | 91.0 (7.4) | 86.6 (14.5) |
| Median (Q1, Q3) | 89.8 (84.3, 95.5) | 79.6 (66.7, 87.5) | 92.2 (87.3, 96.4) | 89.3 (83.3, 94.7) |
| Range | 69.0–100.0 | 14.3–96.4 | 75.0–100.0 | 14.3–100.0 |
| Proportion of IEMs ingestedb | ||||
| Mean (SD) | 58.4 (17.5) | 50.2 (37.4) | 57.6 (26.8) | 56.4 (25.6) |
| Median (Q1, Q3) | 58.0 (49.1, 72.2) | 66.7 (12.5, 69.6) | 60.9 (46.3, 65.2) | 60.0 (45.6, 69.6) |
| Range | 24.1–88.5 | 0.0–96.4 | 5.5–100.0 | 0.0–100.0 |
Notes: Data are presented as %. aOne subject in the schizoaffective disorder group was excluded because they had 0 days of good patch coverage. bIngested IEMs were registered on the digital health data server.
Abbreviations: IEM, ingestible event marker; Q, quartile; SD, standard deviation.