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. 2021 Feb 11;14:37–50. doi: 10.2147/TACG.S276596

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© 2021 Asri et al.

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IgE- mediated wheat allergy. As a result of contact with allergens, IL-25 or IL-33 are secreted from epithelial cells, cause Th2 cell response activation and subsequently IgE antibodies production by B-cells. Inflammatory chemical mediators are released as a result of IgE antibody binding to FceRI receptor on mast cells and basophils as well as to specific epitopes in wheat allergens, causing allergic reactions.

Abbreviations: Ag, antigen; IgE, immunoglobulin E; IL, interleukin; Th2, T helper type 2.