Table 1.
Population Characteristics
| Variables | Protocol U (n = 39) | Protocol C (n = 44) | p |
|---|---|---|---|
| Age | Median 66 IQR(53–78) mean 63.56 SD 17.86 | Median 65 IQR(56.5–75) mean 64.61 sd 15.36 | 0.995 |
| Sex | F 16 (41.0%) | F 24 (54.5%) | 0.219 |
| SOFA | Median 6 IQR (4–8) mean 5.89 SD 2.23 | Median 6 IQR (4–8) mean 5.95 SD 2.27 | 1.000 |
| Lactate (mmol/L) | Median 3.6 IRQ (2.4–5.8) mean 4.70 SD 3.11 | Median 3.6 IQR (2.35–6.25) mean 4.94 SD 3.49 | 0.984 |
| Surgical pathology | 16 (41.03%) | 14 (31.82%) | 0.384 |
| Steroid use | 13 (33.33%) | 18 (40.91%) | 0.476 |
| Antibiotic start time | 0.138 | ||
| 0–2h | 11 (28.21%) | 5 (11.36%) | |
| 2–4h | 18 (46.15) | 23 (52.27%) | |
| >4h | 10 (25.64%) | 16 (36.36%) | |
| Initial MAP | Median 44 IQR (37–49) mean 44.25 SD 8.17 | Median 47.5 IQR (37.5–57.5) mean 47.11 SD 10.16 | 0.088 |
| ICU Days | Median 3 IRQ (2–10) Mean 7.05 SD 9.58 | Median 4 IRQ (2–14) Mean 8.6 SD 10.28 | 0.610 |
| Days of hospitalization | Median 8 IRQ (3–15) Mean 12.97 SD 15.64 | Median 9.5 IRQ (5–18.5) Mean 15.59 SD 16.35 | 0.685 |
| In-hospital mortality | 22 (56.41%) | 27 (61.36%) | 0.647 |
| Infection SIte | 0.362 | ||
| Lung | 10 (25.64%) | 10 (22.73%) | |
| Urine | 6 (15.38%) | 10 (22.73% | |
| CNS | 1 (2.56%) | 2 (4.55%) | |
| Soft tissues | 1 (2.56%) | 4 (9.09%) | |
| Biliary tract | 4 (10.26%) | 8 (18.18%) | |
| GST | 16 (41.03%) | 10 (22.73% | |
| Other | 1 (2.56%) | 0 (0%) | |
Abbreviations: U, USER; C, control; F, female; MAP, mean arterial pressure; CNS, central nervous system; GST, gastric and intestinal; ICU, intensive care unit.