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Composition and physicochemical characteristics of Valacyclovir Hydrochloride ocular inserts
| Formulations | HPCMF (%w/w) | HPMC K4M (%w/w) | Valacyclovir HCl (%w/w) | PEG 400 (%w/w) | Extrusion Temperature (°C) | Weight (mg) | Thickness (mm) | Drug Content (%) |
|---|---|---|---|---|---|---|---|---|
| FI | 75 | - | 20 | 5 | 120 | 5.09 ± 0.72 | 1.00 ± 0.38 | 98.59 ± 0.06 |
| F2 | 65 | 10 | 20 | 5 | 130 | 5.09 ± 1.02 | 1.08 ± 0.12 | 97.69 ± 0.89 |
| F3 | 55 | 20 | 20 | 5 | 130 | 4.98 ± 0.91 | 0.99 ± 0.29 | 101.59 ± 0.10 |
