Table 4.

Candidate Gene Set Enrichment Results Based on TWAS Results From All Tissues, Tissue Sets, and Each Panel

Gene Set	PubMed ID	Estimate	SE	t	p	FDR pa	Tissue
All Tissue Results
RBFOX2	24613350	0.08	0.02	3.26	5.57 × 10−4	3.95 × 10−2	All
Tissue-Set Results
RBFOX2	24613350	0.11	0.03	4.13	1.78 × 10−5	1.26 × 10−3	Brain
SCZ.COMPOSITE	24463508	0.11	0.03	3.64	1.39 × 10−4	4.92 × 10−3	Brain
RBFOX1.RBFOX3	24613350	0.08	0.02	3.45	2.80 × 10−4	6.62 × 10−3	Brain
FMRP	21784246	0.12	0.04	3.35	3.98 × 10−4	7.06 × 10−3	Brain
POTENTIALLY.SYNAPTIC.ALL	27694994	0.06	0.02	3.03	1.21 × 10−3	1.72 × 10−2	Brain
PGC.BP.P10.4	21926972	0.18	0.06	2.85	2.20 × 10−3	2.60 × 10−2	Brain
NEURONAL.PSD	23071613	0.09	0.03	2.67	3.83 × 10−3	3.89 × 10−2	Brain
Tissue-Specific Results
MIR.137	24463508	0.36	0.10	3.58	1.70 × 10−4	1.02 × 10−2	CMC DLPFC RNA-seq
SCZ.DENOVO.NONSYN	24463508	0.40	0.12	3.51	2.25 × 10−4	1.17 × 10−2	GTEx pituitary
SCZ.COMPOSITE	24463508	0.23	0.07	3.28	5.21 × 10−4	1.36 × 10−2	GTEx pituitary
SCZ.COMPOSITE	24463508	0.27	0.08	3.19	7.03 × 10−4	3.24 × 10−2	GTEx basal ganglia
CONSTRAINED	25086666	0.27	0.09	2.97	1.50 × 10−3	3.44 × 10−2	CMC DLPFC RNA-seq
RBFOX1.RBFOX3	24613350	0.12	0.04	2.93	1.72 × 10−3	3.44 × 10−2	CMC DLPFC RNA-seq
PGC.SCZ.P10.4	24463508	0.27	0.10	2.73	3.20 × 10−3	4.79 × 10−2	CMC DLPFC RNA-seq

CMC, CommonMind Consortium; DLPFC, dorsolateral prefrontal cortex; FDR, false discovery rate; GTEx, Genotype Tissue Expression; RNA-seq, RNA sequencing; SE, standard error; TWAS, transcriptome-wide association study.

^aMultiple testing–corrected p value using FDR method.