Table 5.

Hypothesis-free Gene Set Enrichment Results Based on TWAS Results From Each Panel

Gene Set	Estimate	SE	t	p	FDR pa	Tissue
GO.MACROMOLECULAR.COMPLEX.BINDING	0.46	0.09	5.07	1.98 × 10−7	5.99 × 10−4	GTEx basal ganglia
GO.MICROTUBULE.BINDING	1.04	0.22	4.68	1.46 × 10−6	2.20 × 10−3	GTEx basal ganglia
GO.ALCOHOL.BINDING	1.79	0.38	4.66	1.56 × 10−6	5.16 × 10−3	GTEx pituitary
GO.CHROMATIN.BINDING	0.79	0.19	4.19	1.42 × 10−5	1.41 × 10−2	GTEx basal ganglia
GO.PROTEIN.COMPLEX.BINDING	0.44	0.11	4.12	1.87 × 10−5	1.41 × 10−2	GTEx basal ganglia
GO.LIGAND.DEPENDENT.NUCLEAR.RECEPTOR.BINDING	1.98	0.50	3.98	3.47 × 10−5	2.09 × 10−2	GTEx basal ganglia
GO.REGULATION.OF.INTRINSIC.APOPTOTIC.SIGNALING.PATHWAY	1.79	0.43	4.14	1.73 × 10−5	3.30 × 10−2	GTEx amygdala

FDR, false discovery rate; GTEx, Genotype Tissue Expression; SE, standard error; TWAS, transcriptome-wide association study.

^aMultiple testing–corrected p value using FDR method.