Table 1. Categorization of bHLH transcription factors expressed or not expressed during cerebellar development in mice.
| bHLH factors expressed in cerebellar progenitor niches: Rhombic lip (RL), Ventricular zone (VZ) and/or external granule cell layer (EGL) | |||||
|---|---|---|---|---|---|
| Gene name | Expressed in progenitors? | Developmental stage: embryonic (E) day | |||
| E11.5 | E13.5 | E15.5 | E17.5/E18.5 | ||
| Ascl1 | Yes | VZ | VZ | Weak in VZ | Not expressed |
| Atoh1 | Yes | RL | RL and EGL | RL and EGL | RL and EGL |
| Hes1 | Yes | Not expressed | RL and VZ | Not expressed | Not expressed |
| Hes5 | Yes | RL and VZ | RL and VZ | RL and VZ | Postmitotic cells |
| Hes6 | Yes | RL and VZ | RL, VZ and EGL | EGL | No data |
| Hes7 | Yes | RL and VZ | Weak in RL, VZ | Weak in RL, VZ | Not expressed |
| Hey1 | Yes | Not expressed | Not expressed | EGL | EGL |
| Hif1a | Yes | RL and VZ | Weak in RL, VZ | Not expressed | Not expressed |
| Id1 | Yes | RL and VZ | In blood vessels | In blood vessels | In blood vessels |
| Id3 | Yes | RL and VZ | RL, VZ and EGL | RL, VZ and EGL | EGL |
| Max | Yes | Weak in RL and VZ | Not expressed | Not expressed | Not expressed |
| Mxd3 | Yes | RL and VZ | RL, VZ and EGL | EGL | EGL |
| Mxi1 | Yes | Weak in RL and VZ | RL, VZ and EGL | RL, VZ and EGL | Weak in EGL |
| Mycl | Yes | RL and VZ | RL, VZ and EGL | EGL | EGL |
| Mycn | Yes | Strong in RL and VZ | Not expressed | Not expressed | Not expressed |
| Neurod1 | Yes | Not expressed | Not expressed | Strong in EGL | Strong in EGL |
| Neurod6 | Yes | Not expressed | Weak in VZ | VZ | Broad expression |
| Neurog1 | Yes | Not expressed | VZ | Not expressed | Not expressed |
| Neurog2 | Yes | Not expressed | Weak in VZ | Strong in VZ | Not expressed |
| Olig2 | Yes | Weak in VZ | Strong in VZ | Postmitotic cells | Postmitotic cells |
| Olig3 | Yes | RL and weak in VZ | RL and VZ | Not expressed | Not expressed |
| Ptf1a | Yes | Strong in VZ | Strong in VZ | Weak in VZ | Not expressed |
| Srebf1 | Yes | Not expressed | RL, VZ and EGL | Weak in EGL | Not expressed |
| Srebf2 | Yes | Weak in RL and VZ | RL and VZ | Postmitotic cells | Postmitotic cells |
| Tcf12 | Yes | RL and VZ | RL, VZ and EGL | RL, VZ and EGL | RL, VZ and EGL |
| Tcf3 | Yes | RL and VZ | RL, VZ and EGL | RL, VZ and EGL | RL, VZ and EGL |
| Tcf4 | Yes | RL and VZ | RL, VZ and EGL | RL, VZ and EGL | RL, VZ and EGL |
| bHLH factors expressed in postmitotic cerebellar cells during development | bHLH factors not expressed in the cerebellum during development | ||||
| Gene name: | Arntl, Arnt2, Bhlhe22, Clock, Epas1, Id2, id4, Mlx, Mnt, Mxd1, Mxd4, Myc, Ncoa1, Ncoa2, Neurod2, Neurog3, Nhlh1, Nhlh2, Npas3, Npas4, Olig1, Scx, Sim2, Usf1 and Usf2 | Gene name: | Ahr, Ahrr, Arnt, Arntl2, Ascl2, Ascl3, Ascl4, Ascl5, Atoh7, Atoh8, Bhlha15, Bhlha9, Bhlhb9, Bhlhe23, Bhlhe40, Bhlhe41, Ferd3l, Figla, Hand1, Hand2, Helt, Hes2, Hes3, Hes4, Hey2, Heyl, Hif3a, Lyl1, Mesp1, Mesp2, Mitf, Mlxip, Mlxipl, Msc, Myf5, Myf6, Myod1, Myog, Ncoa3, Neurod4, Npas1, Npas2, Sim1, Sohlh1, Sohlh2, Tal1, Tal2, Tcf15, Tcf21, Tcf23, Tcf24, Tcfl5, Tfap4, Tfe3, Tfeb, Tfec, Twist1 and Twist2 | ||