Table 1.
Effect of fisetin on SCI-induced alteration in body weight, food intake, water intake, urine output and urine protein level
| Treatment | Normal | Sham | SCI Control | Methylprednisolone (30) | Fisetin (10) | Fisetin (20) | Fisetin (40) |
|---|---|---|---|---|---|---|---|
| Body weight (g) | 227.20 ± 2.37 | 230.20 ± 0.95 | 169.00 ± 1.93#,& | 219.20 ± 1.85*,$ | 176.80 ± 2.01 | 189.70 ± 0.92*,$ | 211.50 ± 1.75*,$ |
| Food intake (g) | 24.33 ± 0.49 | 21.33 ± 0.76 | 10.50 ± 0.62#,& | 20.00 ± 0.58*,$ | 13.67 ± 0.92 | 16.50 ± 0.67*,$ | 17.83 ± 0.79*,$ |
| Water intake (mL) | 40.67 ± 1.75 | 37.67 ± 0.71 | 23.00 ± 1.21#,& | 35.50 ± 1.50*,$ | 23.83 ± 1.35 | 29.67 ± 1.56*,$ | 34.33 ± 1.54*,$ |
| Volume of urine expressed in 24 h (ml) | 1.17 ± 0.17 | 1.67 ± 0.21 | 5.17 ± 0.17#,& | 2.33 ± 0.21*,$ | 5.00 ± 0.26 | 3.33 ± 0.21*,$ | 2.67 ± 0.21*,$ |
| Urine protein (mg/ml) | 1.66 ± 0.18 | 2.38 ± 0.16 | 6.97 ± 0.26#,& | 3.31 ± 0.16*,$ | 6.63 ± 0.20 | 4.87 ± 0.12*,$ | 3.62 ± 0.14*,$ |
Data are expressed as mean ± SEM (n = 6) and one-way ANOVA followed by Tukey’s multiple range test.
ANOVA, analysis of variance; SCI, spinal cord injury.
#P < 0.05 as compared with sham group.
&P < 0.05 as compared with normal.
*p < 0.05 as compared with the SCI control group.
$P < 0.05 as compared with one another.