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. Author manuscript; available in PMC: 2021 Feb 16.
Published in final edited form as: JOM (1989). 2016 Feb 16;68(4):1128–1133. doi: 10.1007/s11837-016-1841-1

Fig. 2.

Fig. 2.

Microneedle-facilitated delivery of itraconzole to regenerated human basal cell carcinoma. Skin grafts expressing Sonic Hedgehog were generated on immunodeficient mice; topical treatment of itraconazole was facilitated by either four 1 × 4 polyglycolic acid microneedle arrays or stainless steel microneedle arrays. Hematoxylin and eosin staining of 4-week-old regenerated human skin grafts of: (a) untreated control, (b) polyglycolic acid microneedle array-facilitated delivery of itraconazole-containing solution, and (c) stainless steel microneedle array-facilitated delivery of itraconazole-containing solution.