Table 3.
Effect of P. dodecandra Root Extract on Liver Chemistry of Mice
| Group | ALP (IU/L) | ALT (IU/L) | AST (IU/L) | GGT (IU/L) | LDH (IU/L) |
|---|---|---|---|---|---|
| 2%TW80 | 94.61 ± 4.02 | 41.54 ± 3.12 | 32.86 ± 2.76 | 56.14 ± 3.69 | 214.55 ± 6.32 |
| CCl4 | 272.18 ± 7.86a### | 247.26 ± 9.32a### | 215.42 ± 8.68a### | 135.23 ± 4.45 a### | 568.92 ± 12.30 a### |
| Silymarin + CCl4 | 99.41 ± 4.09(97.3)b### | 48.74 ± 4.26(96.5)b### | 36.33 ± 3.27(98.1)b### | 66.40 ± 2.97(87.0) b### | 237.21 ± 8.42(93.6) b### |
| PDRE100 + CCl4 | 251.23 ± 4.28(11.8)a###,c###,d###,e### | 226.28 ± 5.04(10.2) a###,c###,d###,e### | 192.78 ± 6.84(12.4) a###,c###,d###,e### | 127.81 ± 5.22(9.4) a###,c###,d###,e### | 491.67 ± 10.06(21.8) a###,c###,d###,e### |
| PDRE200 + CCl4 | 124.09 ± 5.21(83.4)b###,c#,e# | 64.79 ± 4.89(88.7)b###,c# | 59.15 ± 5.74(85.6)b### | 82.58 ± 3.87(66.6) b### | 252.11 ± 9.78(89.4) b### |
| PDRE400 + CCl4 | 101.71 ± 3.96(96.0)b### | 55.12 ± 4.51(93.4)b### | 41.26 ± 3.44(95.4)b### | 74.38 ± 4.16(76.9) b### | 243.61 ± 8.74(91.8) b### |
Notes: Each value represents mean ± S.E.M; n=6; aAgainst 2%TW80; bAgainst CCl4; cAgainst standard (silymarin); dAgainst PDRE200 + CCl4; eAgainst PDRE400 + CCl4; #p < 0.05, ###p < 0.001.
Abbreviations: PDRE100, Phytolacca dodecandra root extract 100 mg/kg; PDRE200, Phytolacca dodecandra root extract 200 mg/kg; PDRE400, Phytolacca dodecandra root extract 400 mg/kg; Silymarin, silymarin 100 mg/kg; CCl4, carbon tetrachloride 2 mL/kg; 2%TW80, 2% Tween 80 in water.