Table 3.
Subgroup analysis results of all included studies.
| Sensitivity (95% CI) | Specificity (95% CI) | DOR (95% CI) | SROC (AUC ± SE) | |
| TmiRs | 0.70 (0.66–0.74) | 0.87 (0.83–0.90) | 15.53 (8.37–28.85) | 0.8302 ± 0.0402 |
| P/I2 | .0001/73.5% | .0012/67.2% | .0171/55.3% | |
| Specimen type | ||||
| Plasma | 0.75 (0.67–0.82) | 0.88 (0.80–0.94) | 20.94 (6.38–68.76) | 0.8890 ± 0.0361 |
| P/I2 | .0001/86.2% | .0540/60.7% | .0976/52.4% | |
| Serum | 0.68 (0.63–0.73) | 0.86 (0.81–0.90) | 13.75 (6.43–29.42) | 0.7204 ± 0.0828 |
| P/I2 | .0846/48.4% | .0016/74.2% | .0285/60.0% | |
| Control group Composition | ||||
| HC | 0.68 (0.63–0.73) | 0.87 (0.82–0.90) | 12.63 (8.76–18.20) | 0.8096 ± 0.0576 |
| P/I2 | .0244/58.7% | .0084/65.2% | .0700/48.5% | – |
| Non-HC | 0.78 (0.69–0.86) | 0.86 (0.75–0.93) | 42.43 (3.21–560.31) | 0.9622 ± 0.0719 |
| P/I2 | .0005/87.0% | .0063/80.3% | .0142/76.5% | – |
AUC = area under the curve, CI = confidence interval, DOR = diagnostic odds ratio, HC = healthy control, SE = standard error, SROC = summary receiver operating characteristic curves value, TmiRs = total mixed miRNAs.