Table 3.
Univariate Analysis for Predictors of Death.
| Predictors | HR (95% CI) | P a |
|---|---|---|
| Demographic variables | ||
| Age (yr) | 1.048 (1.027-1.068) | < 0.001 |
| Age ≥70 yr (reference <70) | 3.396 (1.938-5.948) | < 0.001 |
| Male (reference female) | 1.074 (0.652-1.769) | 0.778 |
| Presence of comorbidities | 2.255 (1.133-4.360) | 0.016 |
| Number of comorbidities | 1.313 (1.115-1.547) | 0.001 |
| Heart disease | 2.964 (1.730-5.080) | < 0.001 |
| Hypertension | 1.794 (1.087-2.961) | 0.022 |
| Diabetes | 1.125 (0.603-2.102) | 0.711 |
| Chronic kidney disease | 2.364 (1.039-5.378) | 0.040 |
| COVID-19 presentation | ||
| CURB-65 ≥3 (reference 0-1) | 6.99 (3.794-12.884) | < 0.001 |
| Neutrophil count (×1000 cells/μL) | 0.959 (0.881-1.045) | 0.340 |
| Neutrophil <1500 cells/μL | 1.540 (0.860-2.759) | 0.146 |
| Lymphocyte count (×1000 cells/μL) | 1.015 (0.992-1.039) | 0.212 |
| Lymphocyte count <500 cells/μL | 1.526 (0.922-2.527) | 0.100 |
| Lymphocyte count <1000 cells/μL | 1.712 (0.853-3.982) | 0.607 |
| Platelet count (×100 × 109/L) | 0.768 (0.610-0.966) | 0.024 |
| Platelet count <140 × 109/L | 1.764 (0.244-12.753) | 0.574 |
| Hemoglobin (g/dL) | 0.897 (0.807-0.996) | 0.043 |
| C-reactive protein >10 mg/dL | 2.123 (1.275-3.533) | 0.004 |
| Ferritin >1000 μg/L | 1.363 (0.759-2.445) | 0.300 |
| LDH >300 U/L | 1.793 (1.033-3.114) | 0.038 |
| d-dimer (×ULN) | 1.257 (1.013-1.559) | 0.038 |
| Lymphoma characteristics | ||
| High-risk lymphomab (reference low-risk) | 2.756 (1.240-6.122) | 0.013 |
| DLBCL (reference FL) | 2.663 (1.351-5.248) | 0.005 |
| Active treatmentc | 1.182 (0.714-1.956) | 0.515 |
| Active diseased (reference CR) | 2.232 (1.249-3.986) | 0.007 |
P values marked in bold indicate statistically significant results (P < 0.05).
aCox regression.
bHigh risk according to prognostic index at diagnosis.
cLymphoma treatment within the 3 previous month.
dPartial response or progression.
CI = confidence interval; COVID-19 = coronavirus disease-2019; CR = complete response; CURB-65 = confusion, urea concentration, respiratory rate, blood pressure, and age >65; DLBCL = diffuse large B cell lymphoma; FL = follicular lymphoma; HR = hazard ratio; LDH = lactate dehydrogenase; ULN = upper limit of normal.