Table 3.
Stratified meta-analyses of the correlation between UCP2 rs660339 polymorphism and risk of T2DM.
| T vs. C (allele model) | CT+CC vs. TT (dominant model) | CC vs. TT+CT (recessive model) | CC vs. TT (homozygous model) | CT vs. TT (heterozygous model) | ||||||||
| Characteristics | No. of studies | Sample size (case/control) | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P |
| Total | 9 | 3042/2388 | 1.066 (0.887–1.282) | .494 | 1.056 (0.827–1.349) | .663 | 1.132 (0.851–1.506) | .393 | 1.160 (0.803–1.676) | .430 | 1.026 (0.825–1.276) | .820 |
| Ethnicity | ||||||||||||
| Asian | 7 | 2016/1676 | 1.034 (0.825–1.296) | .774 | 0.994 (0.760–1.300) | .962 | 1.126 (0.767–1.653) | .545 | 1.107 (0.695–1.762) | .669 | 0.965 (0.776–1.199) | .745 |
| Caucasian | 2 | 1026/712 | 1.186 (0.777–1.808) | .429 | 1.291 (0.612–2.725) | .502 | 1.148 (0.882–1.494) | .305 | 1.369 (0.655–2.863) | .404 | 1.256 (0.592–2.668) | .553 |
| Source of control | ||||||||||||
| Hospital-based | 2 | 1671/1330 | 1.078 (0.912–1.272) | .379 | 1.083 (0.844–1.388) | .532 | 1.145 (0.840–1.560) | .391 | 1.176 (0.829–1.668) | .363 | 1.054 (0.811–1.370) | .692 |
| Population-based | 4 | 553/591 | 1.182 (0.798–1.751) | .404 | 1.217 (0.743–1.996) | .435 | 1.286 (0.717–2.309) | .399 | 1.431 (0.655–3.127) | .369 | 1.155 (0.770–1.732) | .486 |
| Unknown | 3 | 818/467 | 0.920 (0.775–1.091) | .337 | 0.852 (0.654–1.110) | .235 | 0.963 (0.665–1.395) | .843 | 0.865 (0.607–1.232) | .421 | 0.844 (0.561–1.271) | .418 |
| Genotyping method | ||||||||||||
| Others | 5 | 1989/1665 | 1.001 (0.799–1.254) | .995 | 1.013 (0.737–1.392) | .935 | 0.979 (0.734–1.306) | .886 | 1.005 (0.656–1.542) | .980 | 1.020 (0.765–1.359) | .893 |
| PCR-RFLP | 4 | 1053/723 | 1.164 (0.827–1.637) | .383 | 1.120 (0.723–1.737) | .612 | 1.397 (0.769–2.537) | .272 | 1.422 (0.691–2.925) | .339 | 1.035 (0.698–1.536) | .863 |
| Quality | ||||||||||||
| High | 6 | 2162/1842 | 1.115 (0.856–1.452) | .421 | 1.127 (0.809–1.570) | .480 | 1.191 (0.798–1.776) | .392 | 1.273 (0.749–2.162) | .372 | 1.084 (0.825–1.425) | .562 |
| Low | 3 | 880/546 | 0.975 (0.831–1.144) | .760 | 0.920 (0.682–1.241) | .586 | 1.046 (0.714–1.532) | .819 | 0.966 (0.695–1.343) | .837 | 0.904 (0.600–1.362) | .628 |
CI = confidence interval, OR = odds ratio, PCR-RFLP = polymerase chain reaction-restriction fragment length polymorphis, T2DM = type 2 diabetes mellitus, UCP2 = uncoupling protein-2.