Table 3.

Association between age at diagnosis and progressive disease in patients with Crohn's disease

	OR (95% CI)	P	AUC (95% CI)
Model 1a			0.572 (0.537–0.607)
Age at diagnosis, yr	0.979 (0.970–0.988)	<0.001
Model 2b			0.727 (0.697–757)
Age at diagnosis, yr	0.983 (0.973–0.993)	0.001
Location
L1	1 (Reference)
L2	1.927 (1.295–2.869)	0.001
L3	1.869 (1.389–2.514)	<0.001
Behaviour
B1	1 (Reference)
B2	4.203 (2.955–5.977)	<0.001
B3	4.239 (3.030–5.929)	<0.001
Perianal disease
No	1 (Reference)
Yes	2.759 (1.961–3.882)	<0.001
Follow-up time, median (IQR), yr	0.994 (0.978–1.011)	0.477
Model 3c
Age at diagnosis, yr			0.581 (0.547–0.615)
<18	1 (Reference)
18–30	1.012 (0.698–1.467)	0.951
31–50	0.765 (0.522–1.121)	0.170
51–60	0.714 (0.385–1.324)	0.285
>60	0.349 (0.157–0.774)	0.010
Follow-up time, median (IQR), yr	1.021 (1.006–1.037)	0.006
Model 4d			0.724 (0.693–754)
Age at diagnosis, yr
<18	1 (Reference)
18–30	0.987(0.663–1.469)	0.948
31–50	0.793 (0.525–1.197)	0.269
51–60	0.735 (0.377–1.432)	0.365
>60	0.390 (0.164–0.923)	0.032
Location
L1
L2	1.908 (1.283–2.838)	0.001
L3	1.897 (1.410–2.553)	<0.001
Behaviour
B1	1 (Reference)
B2	4.199 (2.953–5.971)	<0.001
B3	4.222 (3.020–5.904)	<0.001
Perianal disease
No	1 (Reference)
Yes	2.758 (1.961–3.878)	<0.001
Follow-up time, median (IQR), yr	0.995 (0.979–1.012)	0.585

AUC, area under the curve; B1, nonstricturing/nonpenetrating; B2, stricturing; B3, penetrating; CI, confidence interval; IQR, interquartile range; L1, ileal; L2, colonic; L3, ileocolonic; OR, odds ratio.

^aLogistic regression: dependent variable—progressive disease and independent variable—age at diagnosis as a continuous variable.

^bLogistic regression: dependent variable—progressive disease and independent variables—age at diagnosis as a continuous variable, location of disease, behavior of disease, presence of perianal disease, and follow-up time.

^cLogistic regression: dependent variable—progressive disease and independent variables—age at diagnosis as a categorical variable and follow-up time.

^dLogistic regression: dependent variable—progressive disease and independent variables—age at diagnosis as a categorical variable, location of disease, behavior of disease, presence of perianal disease, and follow-up time.