Table 5.

Association between age at diagnosis and progressive disease in patients with ulcerative colitis

	OR (95% CI)	P	AUC (95% CI)
Model 1a			0.578 (0.544–0.611)
Age at diagnosis, yr	0.983 (0.975–0.990)	<0.001
Model 2b			0.714 (0.684–0.744)
Age at diagnosis, yr	0.990 (0.982–0.999)	0.028
Disease extension
E1	1 (Reference)
E2	3.774 (2.693–5.287)	<0.001
E3	5.698 (4.204–7.722)	<0.001
Follow-up time, median (IQR), yr	1.011 (0.996–1.025)	0.150
Model 3c			0.566 (0.497–0.635)
Age at diagnosis, yr
<18	1 (Reference)
18–30	0.533 (0.343–0.827)	0.005
31–50	0.451 (0.293–0.692)	<0.001
51–60	0.362 (0.213–0.617)	<0.001
>60	0.375 (0.207–0.678)	0.001
Follow-up time, median (IQR), yr	1.015 (1.002–1.029)	0.027
Model 4d			0.716 (0.686–0.746)
Age at diagnosis, yr
<18	1 (Reference)
18–30	0.703 (0.440–1.122)	0.139
31–50	0.637 (0.403–1.007)	0.054
51–60	0.567 (0.321–1.001)	0.050
>60	0.560 (0.297–1.055)	0.073
Disease extension
E1	1 (Reference)
E2	3.786 (2.702–5.305)	<0.001
E3	5.654 (4.169–7.668)	<0.001
Follow-up time, median (IQR), yr	1.012 (0.997–1.027)	0.106

AUC, area under the curve; CI, confidence interval; E1, ulcerative proctitis; E2, left side colitis; E3, extensive ulcerative colitis; IQR, interquartile range; OR, odds ratio.

^aLogistic regression: dependent variable—progressive disease and independent variable—age at diagnosis as a continuous variable.

^bLogistic regression: dependent variable—progressive disease and independent variables—age at diagnosis as a continuous variable, disease extension, and follow-up time.

^cLogistic regression: dependent variable—progressive disease and independent variables—age at diagnosis as a categorical variable and follow-up time.

^dLogistic regression: dependent variable—progressive disease and independent variables—age at diagnosis as a categorical variable, disease extension, and follow-up time.