Table 3.

Total and stratified analyses of brain-derived neurotropic factor rs6265 polymorphism and T2DM risk.

			Allelic comparison			Homozygote comparison			Heterozygote comparison			Dominant genetic model			Recessive genetic model
Variables	N∗	Cases/Controls	OR (95%CI)	P †	I 2	OR (95%CI)	P †	I 2	OR (95%CI)	P †	I 2	OR (95%CI)	P †	I 2	OR (95%CI)	P †	I 2
Total	8	1576/1866	1.14 (0.79, 1.65)	.496	91.4	1.13 (0.57, 2.21)	.773	88.6	1.07 (0.78, 1.48)	.677	70.1	1.14 (0.74, 1.75)	.559	85.5	1.10 (0.67, 1.80)	0.706	84.4
Asian only	7	1480/1729	1.16 (0.78, 1.74)	.465	92.6	1.14 (0.55, 2.36)	.732	90.2	1.08 (0.75, 1.56)	.675	74.4	1.16 (0.71, 1.88)	.561	87.6	1.11 (0.65, 1.88)	0.704	86.7
HWE only	6	1413/1467	0.90 (0.71, 1.15)	.414	75.7	0.77 (0.46, 1.3)	.329	75.2	0.90 (0.68, 1.20)	.487	57.1	0.87 (0.63, 1.22)	.423	71.1	0.83 (0.59, 1.15)	0.259	54.5
Control source
Population	5	1274/1282	0.92 (0.64, 1.31)	.635	79.8	0.81 (0.38, 1.72)	.586	80.1	0.9 (0.58, 1.4)	.637	66.3	0.88 (0.53, 1.46)	.617	77.4	0.85 (0.55, 1.33)	0.480	58.5
Hospital	3	302/584	1.63 (0.78, 3.4)	.197	96.0	1.84 (0.54, 6.31)	.331	93.7	1.38 (0.84, 2.28)	.207	75.9	1.71 (0.78, 3.77)	.181	91.9	1.55 (0.57, 4.22)	0.395	92.7
Score
<7	4	741/901	1.01 (0.88, 1.14)	.946	0.0	0.97 (0.73, 1.29)	.824	0.0	1.06 (0.87, 1.29)	.595	0.0	1.04 (0.86, 1.25)	.712	0.0	0.96 (0.75, 1.23)	0.728	0.0
≥7	4	835/965	1.31 (0.52, 3.27)	.564	96.2	1.30 (0.26, 6.52)	.747	94.9	1.16 (0.51, 2.68)	.721	87.0	1.28 (0.43, 3.84)	.661	93.7	1.28 (0.42, 3.93)	0.665	92.8
Sensitivity analysis
Maximal	7	−/−	1.28 (0.90, 1.82)	.169	88.6	1.41 (0.77, 2.55)	.263	82.3	1.19 (0.94, 1.50)	.149	36.3	1.33 (0.92, 1.92)	.129	77.3	1.26 (0.77, 2.05)	0.361	79.6
Minimal	7	−/−	0.94 (0.75, 1.17)	.554	73.5	0.83 (0.52, 1.34)	.449	73.4	0.95 (0.73, 1.25)	.723	55.1	0.93 (0.68, 1.26)	.624	68.9	0.85 (0.64, 1.14)	0.290	49.6

CI = confidence interval, OR = odds ratio.

^∗Number of comparisons.

^†P-value of Z-test for significant test.