Table 1.
Characteristics of the enrolled studies.
| Case | Control | |||||||||||||
| SNP | Gene location | First Author | Yr | Ethnicity | Source of Control | Cancer Type | Smoking Statue | HWE | Common | Heterozygous | Rare | Common | Heterozygous | Rare |
| rs1051730 | 15q25.1 G > A | Takashi et al | 2011 | Asian | HB | LC | mixed | Y | 349 | 25 | 0 | 314 | 10 | 0 |
| Sakoda et al | 2011 | Cacausian | PB | LC | Y (s) | Y | 255 | 373 | 117 | 625 | 690 | 160 | ||
| Ren et al | 2013 | Asian | PB | LC | Y (s) | Y | 127 | 12 | 0 | 124 | 6 | 0 | ||
| Ren et al | 2013 | Asian | PB | LC | N (ns) | Y | 61 | 10 | 0 | 66 | 4 | 0 | ||
| Pérez-Morales et al | 2018 | Cacausian | PB | LC | Y (s) | Y | 45 | 26 | 3 | 138 | 51 | 3 | ||
| Yang et al | 2012 | Asian | HB | LC | mixed | Y | 1007 | 49 | 0 | 1025 | 36 | 0 | ||
| Christopher et al | 2008 | Cacausian | PB | LC | mixed | Y | 687 | 848 | 295 | 445 | 418 | 93 | ||
| Christopher et al | 2008 | Cacausian | PB | LC | Y (s) | Y | 683 | 871 | 301 | 767 | 771 | 193 | ||
| Schwartz et al | 2009 | Cacausian | PB | LC | mixed | Y | 207 | 280 | 95 | 344 | 379 | 121 | ||
| Schwartz et al | 2009 | African American | PB | LC | mixed | Y | 279 | 96 | 10 | 353 | 74 | 5 | ||
| Liu et al | 2008 | Cacausian | HB | LC | Y (s) | Y | 73 | 84 | 37 | 105 | 98 | 15 | ||
| Shiraishi et al | 2009 | Asian | HB | LC | N (ns) | Y | 248 | 16 | 1 | 560 | 15 | 0 | ||
| Shiraishi et al | 2009 | Asian | HB | LC | Y (s) | N | 922 | 61 | 2 | 350 | 10 | 1 | ||
| Zienolddiny et al | 2009 | Cacausian | PB | LC | Y (s) | Y | 110 | 184 | 58 | 174 | 195 | 56 | ||
| Kaur-Knudsen et al | 2010 | Cacausian | PB | LC | Y (s) | N | 112 | 146 | 50 | 4440 | 4181 | 1086 | ||
| VanderWeele et al | 2012 | Cacausian | HB | LC | mixed | Y | 2529 | 3198 | 1135 | 2902 | 3075 | 784 | ||
| Spitz et al | 2008 | Cacausian | PB | LC | N (ns) | Y | 294 | 198 | 55 | 317 | 281 | 55 | ||
| Spitz et al | 2008 | Cacausian | PB | LC | Y (s) | Y | 685 | 869 | 300 | 764 | 770 | 193 | ||
| rs6495309 | 15q25.1 T > C | Yang et al | 2012 | Asian | HB | LC | mixed | Y | 262 | 735 | 562 | 398 | 794 | 485 |
| Sakoda et al | 2011 | Caucasian | PB | LC | Y (s) | Y | 510 | 208 | 28 | 921 | 496 | 60 | ||
| Sun et al | 2018 | Asian | HB | LC | Y (s) | Y | 60 | 88 | 39 | 24 | 44 | 19 | ||
| Sun et al | 2018 | Asian | HB | LC | N (ns) | Y | 25 | 60 | 22 | 54 | 113 | 52 | ||
| Wu et al | 2009 | Asian | PB | LC | mixed | Y | 490 | 1578 | 920 | 622 | 1425 | 832 | ||
| Du et al | 2011 | Asian | HB | LC | Y (s) | Y | 8 | 32 | 20 | 22 | 28 | 10 | ||
| rs3743073 | 15q25.1 C > A | Shen et al | 2012 | Asian | PB | LC | mixed | Y | 124 | 258 | 218 | 186 | 291 | 123 |
| Tekpli et al | 2012 | Caucasians | HB | LC | Y (s) | Y | 132 | 146 | 31 | 136 | 147 | 51 | ||
| Niu et al | 2010 | Asian | PB | LC | N (ns) | Y | 38 | 118 | 56 | 133 | 246 | 106 | ||
| Niu et al | 2010 | Asian | PB | LC | Y (s) | Y | 62 | 123 | 85 | 33 | 37 | 17 | ||
| rs16969968 | 15q25.1 G > A | Sakoda et al | 2011 | Cacausian | PB | LC | Y (s) | Y | 258 | 370 | 115 | 624 | 689 | 163 |
| Gabrielsen et al | 2013 | Cacausian | PB | LC | Y (s) | Y | 125 | 189 | 69 | 12386 | 12685 | 3298 | ||
| Pérez-Morales et al | 2018 | Cacausian | PB | LC | Y (s) | Y | 45 | 27 | 2 | 136 | 52 | 4 | ||
| Falvella et al | 2009 | Cacausian | PB | LC | mixed | Y | 128 | 226 | 113 | 267 | 348 | 124 | ||
| Zienolddiny et al | 2009 | Cacausian | PB | LC | Y (s) | Y | 112 | 186 | 59 | 174 | 194 | 58 | ||
| Ji et al | 2015 | Cacausian | PB | LC | mixed | Y | 514 | 904 | 396 | 750 | 917 | 286 | ||
| Lips et al | 2009 | Cacausian | PB | LC | Y (s) | Y | 1183 | 1560 | 563 | 2470 | 2493 | 633 | ||
| Lips et al | 2009 | Cacausian | PB | LC | N (ns) | Y | 133 | 155 | 54 | 1432 | 1454 | 387 | ||
| Jaworowska et al | 2011 | Cacausian | HB | LC | mixed | Y | 280 | 433 | 129 | 373 | 369 | 99 | ||
| Ito et al | 2012 | Cacausian | HB | LC | mixed | Y | 678 | 37 | 1 | 681 | 34 | 1 | ||
| Weissfeld et al | 2016 | Cacausian | HB | LC | Y (s) | Y | 276 | 378 | 124 | 471 | 545 | 149 | ||
| Islam et sl. | 2013 | Asian | PB | LC | mixed | Y | 58 | 43 | 5 | 72 | 40 | 4 | ||
| Young et al | 2011 | Cacausian | PB | LC | Y (s) | Y | 81 | 69 | 18 | 225 | 205 | 45 | ||
| rs8034191 | 15q25.1 T > C | Christopher et al | 2008 | Cacausian | PB | LC | mixed | Y | 670 | 858 | 303 | 448 | 415 | 97 |
| Christopher et al | 2008 | Cacausian | PB | LC | Y (s) | Y | 685 | 864 | 302 | 762 | 775 | 191 | ||
| Schwartz et al | 2009 | Cacausian | PB | LC | mixed | Y | 185 | 264 | 90 | 326 | 367 | 116 | ||
| Schwartz et al | 2009 | African | PB | LC | mixed | Y | 231 | 119 | 10 | 300 | 106 | 15 | ||
| Shiraishi et al | 2009 | Asian | HB | LC | Y (s) | N | 241 | 17 | 1 | 559 | 15 | 1 | ||
| Shiraishi et al | 2009 | Asian | HB | LC | Y (s) | N | 919 | 64 | 2 | 346 | 13 | 2 | ||
| Liu et al | 2008 | Cacausian | HB | LC | Y (s) | Y | 71 | 77 | 46 | 109 | 81 | 18 | ||
| Zienolddiny et al | 2009 | Cacausian | PB | LC | Y (s) | Y | 117 | 178 | 57 | 176 | 187 | 61 | ||
| Jaworowska et al | 2011 | Cacausian | HB | LC | mixed | Y | 286 | 419 | 128 | 368 | 361 | 102 | ||
| Ito et al | 2012 | Cacausian | HB | LC | mixed | Y | 674 | 41 | 4 | 672 | 43 | 1 | ||
| VanderWeele et al | 2012 | Cacausian | HB | LC | mixed | Y | 2506 | 3243 | 1115 | 2897 | 3083 | 786 | ||
| Weissfeld et al | 2016 | Cacausian | HB | LC | Y (s) | Y | 270 | 374 | 134 | 469 | 546 | 151 | ||
| de Mello et al | 2012 | Cacausian | PB | LC | mixed | Y | 44 | 71 | 29 | 53 | 67 | 24 | ||
| Wang et al | 2012 | Asian | HB | LC | mixed | Y | 350 | 29 | 2 | 385 | 25 | 0 | ||
| Bae et al | 2012 | Asian | HB | LC | mixed | Y | 328 | 544 | 221 | 294 | 535 | 261 | ||
H-B = hospital-based, HWE = Hardy Weinberg equilibrium, LC = lung cancer, mixed = not mentioned, N (ns); sample without smoking, N = controls not conformed to HWE, P-B = population-based, SNP = single nucleotide polymorphism, Y (s) = sample with smoking, Y = controls conformed to HWE.