Table 3.
False-positive report probability values for associations between the risk of lung cancer and CHRNA5/A3/B4 gene.
| Prior probability | ||||||||||
| Genotype | Comparison | Supgroup | Crude OR (95%) | P-value | Stastical power | 0.250 | 0.100 | 0.010 | 0.001 | 0.0001 |
| rs1051730 | A vs G | Overall | 1.321 (1.240–1.408) | <.001 | 0.856 | 0.000 | 0.000 | 0.001 | 0.006 | 0.061 |
| A vs G | Cacausian | 1.285 (1.210–1.364) | <.001 | 0.926 | 0.000 | 0.000 | 0.001 | 0.006 | 0.057 | |
| A vs G | Asian | 1.855 (1.414–2.434) | <.001 | 0.053 | 0.000 | 0.001 | 0.010 | 0.095 | 0.513 | |
| A vs G | HB | 1.585 (1.261–1.993) | <.001 | 0.142 | 0.000 | 0.000 | 0.004 | 0.038 | 0.283 | |
| A vs G | PB | 1.294 (1.200–1.396) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| A vs G | Y (s) | 1.336 (1.267–1.409) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| A vs G | mixed | 1.286 (1.232–1.342) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| A vs G | N | 1.411 (1.205–1.652) | <.001 | 0.691 | 0.000 | 0.000 | 0.001 | 0.008 | 0.075 | |
| A vs G | Y | 1.312 (1.227–1.404) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | Overall | 1.700 (1.583–1.825) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | Cacausian | 1.697 (1.580–1.822) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | HB | 1.694 (1.527–1.880) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | PB | 1.705 (1.547–1.880) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | Y (s) | 1.793 (1.598–2.011) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | mixed | 1.681 (1.532–1.845) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | N | 1.790 (1.277–2.510) | <.001 | 0.014 | 0.001 | 0.004 | 0.037 | 0.282 | 0.797 | |
| AA vs GG | Y | 1.696 (1.577–1.824) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | Cacausian | 1.234 (1.135–1.341) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | Asian | 1.889 (1.429–2.497) | <.001 | 0.045 | 0.000 | 0.001 | 0.012 | 0.110 | 0.553 | |
| AG vs GG | PB | 1.281 (1.149–1.428) | <.001 | 0.997 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | Y (s) | 1.319 (1.220–1.425) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | mixed | 1.234 (1.160–1.313) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | N | 1.492 (1.182–1.882) | <.001 | 0.132 | 0.000 | 0.000 | 0.004 | 0.041 | 0.298 | |
| AG vs GG | Y | 1.280 (1.168–1.402) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | Overall | 1.381 (1.269–1.503) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | Cacausian | 1.326 (1.218–1.443) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | Asian | 1.886 (1.430–2.487) | <.001 | 0.048 | 0.000 | 0.001 | 0.011 | 0.105 | 0.540 | |
| AG+AA vs GG | HB | 1.319 (1.235–1.409) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | PB | 1.358 (1.220–1.512) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | Y (s) | 1.413 (1.313–1.521) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | mixed | 1.324 (1.249–1.405) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | N | 1.554 (1.247–1.938) | <.001 | 0.173 | 0.000 | 0.000 | 0.003 | 0.031 | 0.244 | |
| AG+AA vs GG | Y | 1.365 (1.249–1.491) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | Overall | 1.521 (1.424–1.625) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | Cacausian | 1.519 (1.421–1.623) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | PB | 1.501 (1.371–1.644) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | Y (s) | 1.552 (1.395–1.726) | <.001 | 0.998 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | mixed | 1.507 (1.273–1.784) | <.001 | 0.567 | 0.000 | 0.000 | 0.001 | 0.010 | 0.090 | |
| AA vs AG+GG | Y | 1.520 (1.390–1.663) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| rs6495309 | TT vs CC | mixed | 1.526 (1.354–1.721) | <.001 | 0.981 | 0.000 | 0.000 | 0.001 | 0.006 | 0.054 |
| TC vs CC | Asian | 1.358 (1.135–1.624) | <.001 | 0.461 | 0.000 | 0.000 | 0.001 | 0.012 | 0.108 | |
| TC+TT vs CC | mixed | 1.453 (1.308–1.613) | <.001 | 0.999 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| TT vs TC+CC | HB | 1.338 (1.167–1.535) | <.001 | 0.893 | 0.000 | 0.000 | 0.001 | 0.006 | 0.059 | |
| rs3743073 | A vs C | Asian | 2.419 (1.891–3.095) | <.001 | 0.094 | 0.000 | 0.001 | 0.006 | 0.056 | 0.373 |
| A vs C | PB | 2.419 (1.891–3.095) | <.001 | 0.094 | 0.000 | 0.001 | 0.006 | 0.056 | 0.373 | |
| AA vs CC | Asian | 2.419 (1.891–3.095) | <.001 | 0.094 | 0.000 | 0.001 | 0.006 | 0.056 | 0.373 | |
| AA vs CC | PB | 2.419 (1.891–3.095) | <.001 | 0.094 | 0.000 | 0.001 | 0.006 | 0.056 | 0.373 | |
| AC vs CC | Asian | 1.477 (1.190–1.833) | <.001 | 0.195 | 0.000 | 0.000 | 0.003 | 0.028 | 0.223 | |
| AC vs CC | PB | 1.477 (1.190–1.833) | <.001 | 0.195 | 0.000 | 0.000 | 0.003 | 0.028 | 0.223 | |
| AC+AA vs CC | Asian | 1.769 (1.444–2.167) | <.001 | 0.266 | 0.000 | 0.000 | 0.002 | 0.021 | 0.174 | |
| AC+AA vs CC | PB | 1.769 (1.444–2.167) | <.001 | 0.266 | 0.000 | 0.000 | 0.002 | 0.021 | 0.174 | |
| rs16969968 | A vs G | Overall | 1.333 (1.285–1.383) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 |
| A vs G | Cacausian | 1.333 (1.285–1.384) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| A vs G | HB | 1.261 (1.148–1.385) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| A vs G | PB | 1.347 (1.294–1.401) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| A vs G | Y (s) | 1.317 (1.258–1.378) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| A vs G | mixed | 1.393 (1.302–1.491) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | Overall | 1.782 (1.649–1.926) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | Cacausian | 1.783 (1.649–1.927) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | HB | 1.555 (1.266–1.909) | <.001 | 0.253 | 0.000 | 0.000 | 0.002 | 0.022 | 0.181 | |
| AA vs GG | PB | 1.824 (1.677–1.985) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | Y (s) | 1.743 (1.583–1.920) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs GG | mixed | 1.922 (1.665–2.218) | <.001 | 0.843 | 0.000 | 0.000 | 0.001 | 0.007 | 0.062 | |
| AG vs GG | Overall | 1.334 (1.262–1.410) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | Cacausian | 1.334 (1.262–1.411) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | HB | 1.327 (1.157–1.523) | <.001 | 0.890 | 0.000 | 0.000 | 0.001 | 0.006 | 0.059 | |
| AG vs GG | PB | 1.336 (1.257–1.419) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | Y (s) | 1.310 (1.224–1.402) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG vs GG | mixed | 1.433 (1.291–1.590) | <.001 | 0.999 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | Overall | 1.426 (1.353–1.502) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | Cacausian | 1.426 (1.353–1.504) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | HB | 1.369 (1.202–1.561) | <.001 | 0.953 | 0.000 | 0.000 | 0.001 | 0.006 | 0.057 | |
| AG+AA vs GG | PB | 1.437 (1.357–1.521) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | Y (s) | 1.398 (1.311–1.491) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AG+AA vs GG | mixed | 1.537 (1.392–1.696) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | Overall | 1.514 (1.410–1.625) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | Cacausian | 1.514 (1.410–1.626) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | HB | 1.320 (1.092–1.595) | <.001 | 0.366 | 0.000 | 0.000 | 0.002 | 0.015 | 0.133 | |
| AA vs AG+GG | PB | 1.549 (1.435–1.672) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | Y (s) | 1.503 (1.375–1.643) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| AA vs AG+GG | mixed | 1.555 (1.368–1.767) | <.001 | 0.953 | 0.000 | 0.000 | 0.001 | 0.006 | 0.055 | |
| rs8034191 | C vs T | Overall | 1.273 (1.166–1.390) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 |
| C vs T | Cacausian | 1.288 (1.243–1.334) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| C vs T | HB | 1.294 (1.111–1.508) | .025 | 0.743 | 0.000 | 0.000 | 0.001 | 0.007 | 0.070 | |
| C vs T | PB | 1.309 (1.232–1.391) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| B vs A | Y (s) | 1.347 (1.187–1.529) | <.001 | 0.958 | 0.000 | 0.000 | 0.001 | 0.006 | 0.055 | |
| B vs A | mixed | 1.208 (1.072–1.361) | .050 | 0.983 | 0.000 | 0.000 | 0.001 | 0.006 | 0.054 | |
| B vs A | Y | 1.254 (1.149–1.369) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BB vs AA | Overall | 1.529 (1.254–1.863) | <.001 | 0.302 | 0.000 | 0.000 | 0.002 | 0.018 | 0.156 | |
| BB vs AA | Cacausian | 1.683 (1.559–1.816) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BB vs AA | PB | 1.692 (1.482–1.931) | <.001 | 0.930 | 0.000 | 0.000 | 0.001 | 0.006 | 0.057 | |
| BB vs AA | Y (s) | 1.752 (1.296–2.369) | <.001 | 0.028 | 0.001 | 0.002 | 0.019 | 0.165 | 0.665 | |
| BB vs AA | Y | 1.546 (1.267–1.887) | <.001 | 0.290 | 0.000 | 0.000 | 0.002 | 0.019 | 0.162 | |
| BA vs AA | Overall | 1.271 (1.170–1.380) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA vs AA | Cacausian | 1.257 (1.193–1.324) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA vs AA | PB | 1.315 (1.204–1.437) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA vs AA | Y (s) | 1.275 (1.150–1.414) | <.001 | 0.999 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA vs AA | mixed | 1.239 (1.110–1.383) | <.001 | 0.996 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA vs AA | Y | 1.236 (1.176–1.299) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA+BB vs AA | Overall | 1.336 (1.215–1.469) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA+BB vs AA | Cacausian | 1.344 (1.279–1.412) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA+BB vs AA | PB | 1.391 (1.279–1.513) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA+BB vs AA | Y (s) | 1.368 (1.241–1.508) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BA+BB vs AA | mixed | 1.274 (1.118–1.452) | <.001 | 0.938 | 0.000 | 0.000 | 0.001 | 0.006 | 0.056 | |
| BA+BB vs AA | Y | 1.313 (1.196–1.442) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BB vs BA+AA | Overall | 1.352 (1.139–1.605) | <.001 | 0.537 | 0.000 | 0.000 | 0.001 | 0.010 | 0.094 | |
| BB vs BA+AA | Cacausian | 1.475 (1.315–1.655) | <.001 | 0.991 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BB vs BA+AA | HB | 1.389 (1.034–1.866) | <.001 | 0.032 | 0.001 | 0.002 | 0.017 | 0.148 | 0.635 | |
| BB vs BA+AA | PB | 1.466 (1.297–1.658) | <.001 | 0.972 | 0.000 | 0.000 | 0.001 | 0.006 | 0.054 | |
| BB vs BA+AA | Y (s) | 1.532 (1.150–2.042) | <.001 | 0.038 | 0.000 | 0.001 | 0.014 | 0.129 | 0.569 | |
| BB vs BA+AA | mixed | 1.344 (1.246–1.449) | <.001 | 1.000 | 0.000 | 0.000 | 0.001 | 0.006 | 0.053 | |
| BB vs BA+AA | Y | 1.363 (1.147–1.619) | <.001 | 0.530 | 0.000 | 0.000 | 0.001 | 0.010 | 0.095 | |
H-B = Hospital-based, P-B = Population-based, Y (s) = sample with from smoking.