Figure 6.

Specific antibody responses in USP21^fl/flFOXP3^Cre mice infected with S. japonicum. (a–d) Serum collected from the WT and KO mice in the NC and INF groups (n = 26 ± 2/group) at different stages of the infection (uninfected, day 20, day 30, day 42). (a) Comparison of the changes in the anti-SEA IgG content. The data are presented as the means ± SD. For the comparison between infection groups, ^∗p = 0.01 on day 20, ^∗∗p < 0.001 on day 30, and^∗∗p < 0.001 on day 42. (b) Comparison of the anti-SEA IgM content. The data are presented as the means ± SD, and ^∗∗p = 0.002 on day 42 when comparing between the infection groups. (c) Comparison of the anti-SWAP IgG contents. The data are presented as the means ± SD; for the comparison between infection groups, ^∗∗p < 0.001 on day 20, ^∗∗p = 0.003 on day 30, and ^∗∗p < 0.001 on day 42. (d) Comparison of the anti-SWAP IgM contents. The data are presented as the means ± SD. For the comparison between infection groups, ^∗∗p < 0.001 on day 20, ^∗∗p = 0.004 on day 30, and ^∗∗p < 0.001 on day 42.