Table 3.
Characteristics of the studies included in the systematic review and meta-analyses
| Variable | Yu | Kim | Xu | Cakici | Inagaki | Huang |
|---|---|---|---|---|---|---|
| Center | Single center, China | Single center, Korea | Single center, China | Single center, Turkey | Single center, Japan | Single center, China |
| Ethnicity | 100% Asian | 100% Asian | 100% Asian | European | 100% Asian | 100% Asian |
| Number of patients | 132 | 61 | 104 | 75 | 74 | 275 |
| F/U, months | 64 ± 45 | 49 (25–102) | 40 (12–145) | 82 (12–194) | 68.0 ± 33.0 | 56 (30–86) |
| Age, years | 32 ± 13 | 34.1 ± 16.4 | 10 (4–17) | 10.1 ± 2.54 | 47.8 ± 17.4 | 33 ± 17 |
| M:F | 0.85:1 | 1.2:1 | 1.26:1 | 1.6:1 | 0.9:1 | 1.08:1 |
| Proteinuria, g/day | 1.6 (0.8–2.8) | 1.69 ± 2.27 | 1.7 (0.1–10.8) | NA | 1.40 (0.7–2.4) | NA |
| eGFR, mL/min/1.73 m2 | 104 ± 33 | 92.6 ± 22.4 | 161 ± 48 | NA | 76.4 ± 25.8 | NA |
| MAP, mmHg | 93 (83–97) | 91.5 ± 9.5 | 82 ± 11 | NA | NA | NA |
| HT, % | 31 | 30 | NA | NA | 35.1 | NA |
| RASB, % | 94 | 53 | NA | NA | 75.7 | 35 |
| Immunosuppression after renal biopsy, % | 62 | 50 | 100 | 42.60 | 82.4 | 72.70 |
| Immunosuppression before renal biopsy | Yes | NA | NA | No | NA | NA |
| Endpoint definition | ≥50% eGFR decline or ESRD | eGFR <60, ≥30% eGFR decline or ESRD | ≥50% eGFR decline or eGFR <90 | eGFR <90 or ≥50% eGFR decline | ≥30% eGFR decline or ESRD | ≥30% eGFR decline, doubling of Scr or ESRD |
| Number of endpoints | 63 | 13 | 8 | 11 | 14 | 30 |
| Number of ESRD events | 8 | 3 | NA | 5 | 1 | 12 |
| Number of pathologists | 2, blinded | 1, blinded | 2, blinded | 2, blinded | 2 | 1, blinded |
| M0/M1 | 67/33 | 85/15 | 49/51 | 38.7/61.3 | 93.2/6.8 | 85.1/14.9 |
| E0/E1 | 43/57 | 85/15 | 74/26 | 56/44 | 48.6/51.4 | 70.2/29.8 |
| S0/S1 | 36/64 | 66/34 | 52/48 | 77.4/22.6 | 48.6/51.4 | 45.8/54.2 |
| T0/T1/T2 | 80/13/7 | 87/13 (T1/2) | 82/18 (T1/2) | 86.7/9.3/4 | 75.7/18.9/5.4 | 97.1/2/0.9 |
| C0/C1/C2 | 37/46/17 | NA | 37/63 (C1/2) | 48/52 (C1/2) | 29.7/47.3/23 | 36/51.3/12.7 |
| Statistical methods | Cox regression | Cox regression | Cox regression | Cox regression | Cox regression | Cox regression |
| Multivariate analysis | MEST-C | ETC | MEST-C | EST | ETC | ESTC |
| Adjusted factors | Age, gender, MAP, proteinuria, eGFR | Proteinuria, hypertension, eGFR | Proteinuria, MAP, eGFR | Proteinuria, eGFR | Age, proteinuria | Age, proteinuria, eGFR |
F/U, follow-up; NA, not available; HT, hypertension; Scr, serum creatinine.