Figure 3.

Beneficial effects of irisin on neuronal function 24 h after SAH. (A,B) Treatment with irisin significantly improved neurological deficits at 24 h after SAH and 300 μg/kg irisin was selected as the effective dose, n = 6 per group. The modified Garcia scores were represented as mean ± SD; the one-way ANOVA was used followed by the Tukey's HSD post-hoc test and the Holm–Bonferroni correction method. The beam balance test scores were represented as median 25–75th percentiles, and the Mann–Whitney U-test and the Kruskal–Wallis test followed by the Steel–Dwass test for multiple comparisons were used to analyze the difference between groups. **P < 0.01, ^##P < 0.01 vs. SAH + Vehicle group. Vehicle group, sterile 0.9% of NaCl; SAH, subarachnoid hemorrhage.