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. 2021 Feb 3;13:640215. doi: 10.3389/fnagi.2021.640215

Figure 7.

Figure 7

Inhibition of UCP-2 pathway blunted the beneficial effect of irisin treatment on short-term neurologic function after SAH. (A,B) Genipin significantly blunted the protective effect of irisin treatment on neurological deficits at 24 h after SAH, n = 6 for each group. The modified Garcia test scores were represented as mean ± SD; the one-way ANOVA was used followed by the Tukey's HSD post-hoc test and the Holm–Bonferroni correction method. The beam balance test scores were represented as median 25th−75th percentiles, and the Mann–Whitney U-test and the Kruskal–Wallis test followed by the Steel–Dwass method of multiple comparisons were used to analyze the difference between groups. **P < 0.01, ***P < 0.001 vs. Sham group; ##P < 0.01, ###P < 0.001 vs. SAH + Vehicle group; &P < 0.05, &&&P < 0.001 vs. SAH + irisin + Vehicle group. Vehicle group, sterile 0.9% of NaCl; SAH, subarachnoid hemorrhage.