Table 3.

Peptide 1.0 and its variant sequences.

Peptide name	Peptide sequence	Peptide length	Cycle length
1.0	TINESISHS$\text{R}$TEDETRTQILS	21	0
1.1	TINES$\text{C}$SHS$\text{R}$TEDETRTQ$\text{C}$LS	21	14
1.2	T$\text{C}$NESISHS$\text{R}$TEDETRTQ$\text{C}$LS	21	18
2.0	TINESISHS$\text{A}$TEDETRTQILS	21	0
3.0	TINESISHS$\text{R}$TEDETR$\text{M}$QILS	21	0
4.0	TIN$\text{Q}$SISHS$\text{R}$T$\text{QNQ}$TRTQILS	21	0
4.1	TIN$\text{Q}$S$\text{C}$SHS$\text{R}$T$\text{QNQ}$TRTQ$\text{C}$LS	21	14
4.2	T$\text{C}$N$\text{Q}$SISHS$\text{R}$T$\text{QNQ}$TRTQ$\text{C}$LS	21	18
4.3	TIN$\text{QC}$SHS$\text{R}$T$\text{QNQ}$TRTQ$\text{C}$LS	20	14

Amino acid substitutions and introduction of cyclized motifs are highlighted in red. The Arg286 position is shown in green. The mass spectrometry datasets presented in this study can be found in online repositories. The name of the repository and accession number can be found at: MassIVE MSV000086480.