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. 2021 Feb 16;10(4):e12064. doi: 10.1002/jev2.12064

FIGURE 7.

FIGURE 7

Basolateral sEV derived from human primary PTEC under inflammatory conditions induce PBMC production of chemokines (MCP‐1, IL‐8) and anti‐inflammatory cytokine IL‐10. MCP‐1 (a), IL‐8 (b) and IL‐10 (c) production by PBMC following 24 h culture alone (‐sEV) and in the presence of apical or basolateral sEV derived from normal (N) or inflammatory (IFN) PTEC. One representative donor experiment is shown (left panel). Fold change (concentration in response to basolateral sEV/concentration in response to apical sEV; basolateral/apical) in chemokine/cytokine production by PBMC for normal (N) and inflammatory (IFN) PTEC‐derived sEV is shown (right panel); Eight individual donor PTEC experiments are presented, with symbols representing individual donor PTEC experiments. *P < 0.05, Wilcoxon matched‐pairs signed‐rank test.