Table 5.
Tissue sealants in the management of post-bariatric leak/fistula—characteristics of endoscopic procedures
| Study | Sealant, no of patients | Amount of sealant per session | No of sessions | Intervals between sessions | Success and failure | Complications of sealing | Time from surgery to endoscopic treatment | Time from first sealing to fistula closure | Interval between treatment and discharge | Follow-up (time and imaging) |
|---|---|---|---|---|---|---|---|---|---|---|
| Assalia A/2018 | (24) Fibrin glue, Evicell | 5 ml | 1–9 pts, 2–8 pts, 3–3 pts, 5–2 pts, 6–1 pts | 2 weeks | 23/1 (95.8%) | Pain (2), fever (1) | The fistula was acute in 10 patients, subacute in 9 and chronic in 5 | 1–90, Median 22 days | NA | 42.3 months (range 20–46) |
| Brolin R/2013 | (7) Fibrin glue, Tisseel | Large amounts |
1–3 pts, 2–1 pts, 3–3 pts |
3 days | 7/7 (100%) | None | 1 day-3 months, median 3 days | NA | Mean 27 days in the operated group and 18 days in fibrine glue group | NA |
| Papavramidis/ 2001 | (2) Fibrin glue, Beriplast | 2 ml | 1–1 pt, 6–1 pt | 2 days | 2/0 (100%) | None | 12 days, 20 days | 2, 34 days | NA | 1 pt-24 months gastroscopy, 2 pt- NA |
| Papavramidis/2004 | (3) Fibrin glue, Beriplast | 2–4 ml | 3–2 pts, 9–1 pt | 2 days | 3/0 (100%) | None | 18, 7, 7 days | 18, 48, 14 days | NA | NA |
| Papavramidis/ 2009 | (3) Fibrin glue Beriplast | Large amounts | 3–1 pt, 6–2 pts | 2 days | 3/0 (100%) | None | 11, 5, 144 days | 15, 16, 26 days | 17, 15, 25 days | NA |
| Kowalski Ch/2007 | (5) Fibrin glue,Tisseel | 10 ml | 1–4 pts, 2–1 pt | NA | 5/0 (100%) | None | 5,7,9,15,33 days | Mean 4 days | 3, 4, 4, 7, 10 days | 12 months |
| Garcia-Caballero M/2005 | (1) Tissucol | 4 ml | 1 | – | 1/0 (100%) | None | 14 days | 4 days | 28 days | 24 months |
| Ece I 2015 | (2) Tisseel | 4 ml | 1–2 pts | – | 2/0 (100%) | None | 14 days | 5 days | 7,9 days | NA |
| Kotzampassi K/2015 | Fibrine glue (Tissucol, Beriplast), Histoacryl | 2 ml |
Fibrin glue: 1–14, median 4; Histoacryl: 1–9, median 4 |
2–3 days | 13/14 (92.8%) | None | 8 days | NA | 8–32, mean 14 days | 3 months |
| Kim SY/2017 |
(1) Fibrin glue, Greenplast; (1) histoacryl |
2 ml | 1 | – | 2/0 (100%) | None |
1st pt-NA 2nd pt-2 weeks |
1,6 days | NA | NA |
NA data not available