Table 1.

Some Macromolecule Radiosensitizers Discussed in This Paper

Type	Name	Mechanism of Radiosensitivity	Reference
Proteins and Peptides	HER3-ADC	Inhibiting DNA damage repair	130
	SYM004	Inhibiting DNA double strand breaks repair and inducing apoptosis	120
	Cetuximab	Increasing radiation-induced apoptosis and DNA damage	131
	Nimotuzumab	Increasing radiation-induced apoptosis and DNA damage	131
	AMG102	Inhibiting DNA damage repair and increasing radiosensitivity of glioblastoma multiforme	132
	C-reactive peptide	Used as radiotherapy targets	133
	HSP	Used as radiotherapy targets	134
	Paraoxonase-2	Used as radiotherapy targets	135
	ECI301	Assisted by HSP-70 and HMGB1	134
miRNAs	miR-621	Targeting SETDB1	141
	miR-205	Targeting zinc finger E-box binding homeobox 1 (ZEB1) and the ubiquitin-conjugating enzyme Ubc13	142
	miR-144-5p	Targeting ATF2	143
	miR-146a-5p	Activating DNA repair pathway	144
	miR-150	Acting on AKT pathway	145
	miR-99a	Targeting mTOR pathway	146
	miR-139-5p	Repressing multiple gene networks of DNA repair and ROS defense	147
	miR-320a	Inducing cancer cell apoptosis	148
siRNAs		Silencing genes related to radioresistance	151–155
Oligonucleotides		Regulating gene expression	156–159