Table 3.
Metabolism- and genome instability-associated cancer hallmarks.
| Cancer type | Mechanism | Reference |
|---|---|---|
| Deregulating cellular energetics- aerobic glycolysis | ||
| Breast | Obesity promotes the progression via the NLRC4 activation | (42) |
| Colitis-associated cancer | NLRP3 activation increases IL-1β in response to glycolysis | (86) |
| Lung | NALP3 ablation led to decreased glycolysis and enhanced mitochondrial respiration, may play a tumor-promoting role in NSCLC | (83) |
| NPC | Activation of glycolysis activates NLRP3 and finally changes the environment of malignant cells resulting in NPC-derived MDSC | (84) |
| Genome instability | ||
| Lung | ATX transfection induces NLRP3 activation and DNA damages | (87) |
| Skin | NLRP3 is activated by UVB-induced DNA damage and releases inflammatory mediators | (88) |