TABLE 1.
Details of 13 hub genes.
| Gene symbols | Degrees | Full names | Gene function |
| CXCL8 | 41 | C-X-C motif chemokine ligand 8 | It is mainly secreted by neutrophils and acts as a chemokine to guide neutrophils to the site of infection |
| MMP9 | 40 | Matrix metallopeptidase 9 | Matrix metalloproteinase (MMP) family of proteins are mainly involved in the breakdown of extracellular matrix |
| CXCL10 | 34 | C-X-C motif chemokine ligand 10 | The binding of this protein to CXCR3 can include stimulating the migration of monocytes, natural killer cells and T cells, and regulating the expression of adhesion molecules |
| STAT1 | 30 | Signal transducer and activator of transcription 1 | Acts as a transcription factor to mediate the expression of multiple genes |
| CXCL1 | 29 | C-X-C motif chemokine ligand 13 | As a chemokine of neutrophils, it plays an important role in inflammation |
| S100A7 | 28 | S100 calcium binding protein A7 | The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities |
| CCL20 | 27 | C-C motif chemokine ligand 20 | The protein shows chemotactic activity on lymphocytes and can inhibit proliferation of myeloid progenitors |
| CXCL9 | 26 | C-X-C motif chemokine ligand 9 | Combined with CXCR3, it can chemoattract lymphocytes instead of neutrophils |
| IRF7 | 22 | Interferon regulatory factor 7 | IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes |
| IVL | 22 | Involucrin | Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase |
| CXCR4 | 22 | C-X-C motif chemokine receptor 4 | It is a specific receptor for chemokine stromal cell-derived factor 1 (CXC12) |
| SPRR1B | 20 | Small proline rich protein 1B | The protein can be cross-linked with membrane proteins by transglutaminase to form an insoluble layer under the plasma membrane |
| CCR7 | 20 | C-C motif chemokine receptor 7 | This receptor-mediated signal can regulate T cell homeostasis in lymph nodes, and may also play a role in the activation and polarization of T cells and the pathogenesis of chronic inflammation |