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. 2021 Feb 3;7:617277. doi: 10.3389/fcvm.2020.617277

Table 5.

Other biological functions of MI circulating biomarkers.

Biomarkers Application value References
S100 S100A8 Prevents myocardial ischemia and stabilize cardiac function after MI (14)
S100B, S100A6, S100P *Associate with ischemic myocardial injury in ACS
* Relate to myocardial infarct size
(129)
S100B *Down-regulate cardiac myocyte hypertrophy and apoptosis
*Affect myocardial metabolism
(74, 75)
IL sIL-1R2, IL-1, IL-6 Associated with myocardial remodeling after MI (64, 65, 100)
H-FABP *Involved in in-stent restenosis
*Evaluate the degree of heart reperfusion after ischemic attack
*Predict adverse cardiac events and provide risk evaluation
(57, 58, 60, 9294)
IGF-1 *Affect atherosclerosis progression
* Reduce adverse cardiac remodeling after cardiac I/R injury
* Improve ventricular arrhythmia after myocardial infarction combined with HGF
(102, 105, 106)
microRNAs microRNA-145 Prognosticate cardiac function and the risk of developing HF (40)
microRNA-1,microRNA-133, microRNA-208 Diagnose sudden death due to early AMI sensitively (138)
microRNA-124 Reduce cardiomyocyte apoptosis following MI (41)
microRNA-208b Reduces post-infarction myocardial fibrosis in (139)
microRNA−93 Inhibit cardiac remodeling and HF (140)
miR-24-3p Exert cardioprotective effects in myocardial I/R injury (141)
VEGF VEGF-A Inversely correlated with LVEF after MI at 6-month follow-up (45)
VEGF-C Predict all-cause mortality independently (113)